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IP Update: Recent Patents Awarded to Waters, Bruker, Quest Diagnostics, and More

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Recent Patents of Interest in Proteomics

US Patent No. 8,123,949. Methods for separating compounds. Inventors: Martin Gilar, Uwe Neue. Assignee: Waters

Covers techniques and equipment for analyzing samples via multi-dimensional chromatography.


US Patent No. 8,119,982. Method and system for mass spectrometry data analysis. Inventor: Shigeki Kajihara. Assignee: Shimadzu

Covers a method of identifying proteins analyzed via mass spec by setting mass windows and then integrating values of the ion intensities of the peaks in these mass windows to create a mapping image for each mass window, which can then be grouped by evaluating the similarity of these images.


US Patent No. 8,119,418. Monitoring treatment of colorectal cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples. Inventors: Heinrich Roder, Maxim Tsypin, Julia Grigorieva. Assignee: Biodesix

Covers a method of using mass spec analysis of blood samples combined with a classification algorithm to determine whether a colorectal cancer patient has developed resistance to treatment with a drug targeting an epidermal growth factor receptor pathway.


US Patent No. 8,119,417. Monitoring treatment of head and neck cancer patients with drugs EGFR pathway using mass spectrometry of patient samples. Inventors: Heinrich Roder, Maxim Tsypin, Julia Grigorieva. Assignee: Biodesix

Covers a method of using mass spec analysis of blood samples combined with a classification algorithm to determine whether a head and neck cancer patient has developed resistance to treatment with a drug targeting an epidermal growth factor receptor pathway.


US Patent No. 8,119,356. Identification method of glycoproteins using a specific lectin precipitation. Inventors: Jeong-Heon Ko, Yong-Sam Kim, Hyang-Sook Yoo, Jong-Shin Yoo, Se-Jeong Oh, Cheorl-Ho Kim, Ok-Lye Son. Assignee: Korea Research Institute of Bioscience and Biotechnology

Covers a method for measuring changes in glycosylation in glycoproteins linked to tumor growth and metastasis.


US Patent No. 8,119,355. Biomarkers for cancer sensitivity and uses thereof. Inventors: Robert Kimberly, Tong Zhou, Takeshi Isoyama. Assignee: The UAB Research Foundation

Covers biomarkers, including protein biomarkers for use in evaluating a patient's sensitivity to a cancer therapy.


US Patent No. 8,114,633. Methods for differentiating plasma-derived protein from recombinant protein in a sample. Inventors: Alfred Weber, Peter Turecek, Hans-Peter Schwarz. Assignee: Baxter International

Covers a technique for detecting and quantifying plasma-derived proteins and recombinant proteins in a sample based on differences in protein glycosylation.


US Patent No 8,110,793. Tandem mass spectrometry with feedback control. Inventors: Roman Zubarev, Mikhail Savitski, Michael Nielsen. Assignee: Bruker

Covers a mass spectrometer providing real-time calculations of quality coefficients for fragment ion spectra for the purpose of determining whether that spectra can be used for identifying a biopolymer molecule or whether it should be acquired once more.


US Patent No. 8,110,371. Identifying organ damage. Inventors: James Dear, David Webb. Assignee: The University Court of the University of Edinburgh

Covers a protein biomarker for determining whether a patient has or is at risk of developing paracetamol-induced liver damage.


US Patent No. 8,110,351. Method for isolating nucleic acids and protein from a single sample. Inventor: Marie Bosnes. Assignee: Invitrogen Dynal

Covers a method of isolating nucleic acid and protein from the same sample by binding them to solid supports.


US Patent No. 8,106,351. Mass spectrometry assay for plasma-renin. Inventors: Cory Bystrom, Richard Reitz, Nigel Clarke. Assignee: Quest Diagnostics

Covers methods for measuring renin activity in plasma samples via mass spectrometry by measuring levels of angiotensin 1 in a sample.


US Patent No. 8,105,982. Aptamers and methods for their in vitro selection and uses thereof. Inventors: Sharon Doyle, Michael Murphy. Assignee: University of California

Covers an in vitro selection protocol for DNA aptamer production that relies on magnetic separations and eliminates the need for expensive robotic systems.


US Patent No. 8,101,423. Label-free high-throughput optical technique for detecting biomolecular interactions. Inventors: Brian Cunningham, Jane Pepper, Bo Lin, Peter Li. Assignee: SRU Biosystems

Covers a label-free optical detection technique for detecting biomolecular interactions including protein-protein interactions.

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.