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IP Update: Recent Patents Awarded to Thermo Fisher, Waters, Microsoft, and More

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Recent Patents of Interest in Proteomics

US Patent No. 8,428,889. Methods of automated spectral peak detection and quantification having learning mode. Inventor: David Wright. Assignee: Thermo Finnigan

Covers a method of automatically identifying and characterizing spectral peaks by generating baseline-corrected spectra, detecting and characterizing peaks in this spectra, and then adjusting these values based on adjustments provided by the user.


US Patent No. 8,426,808. Method of mass spectrometry. Inventors: Emmanuelle Claude; Marten Snel; Johannes Vissers; Petrus Cornelis; Keith Richardson. Assignee: Waters

Covers a method of imaging a substrate wherein a sample of interest in ionized at multiple known positions after which the spectrum of the ionized sample at these positions is produced via a mass spectrometer.


US Patent No. 8,426,155. Proteome analysis in mass spectrometers containing RF ion traps. Inventors: Ralf Hartmer; Jochem Franzen. Assignee: Bruker Daltonik

Covers proteome analysis using an RF ion trap in which digested peptide ions are reduced in charge state enabling high sensitivity detection. Repeating this process over adjacent isolation mass windows allows for the measurement of large numbers of peptides in a single run.


US Patent No. 8,426,151. Systems and methods for the detection of biomarkers. Inventors: Richard Selinfreund; Rakesh Vig; Richard Gill. Assignee: Companion Diagnostics.

Covers a biomarker detection system using a plurality of wells each of which contains at least one detection agent and a device capable of detecting interactions between the detection agent and target biomarkers.


US Patent No. 8.426,150. Process for differential polypeptides detection and uses thereof. Inventor: Rongxiu Li. Assignee: NA

Covers affinity media and its use for detection of differential proteins and peptides by depletion of proteins and peptides similar to those in a control sample from a test sample.


US Patent No. 8,420,337. Lipoprotein-associated markers for cardiovascular disease. Inventors: Jay Heinecke; Tomas Vaisar. Assignee: University of Washington

Covers use of biomarkers comprising at least one of ApoC-IV, Paraoxonase 1, C3, C4, ApoA-IV, ApoE, ApoL1, C4B1, Histone H2A, ApoC-II, ApoM, Vitronectin, Haptoglobin-related protein, and Clusterin, or combinations thereof to diagnose and predict risk of cardiovascular disease.


US Patent No. 8.420,333. G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker. Inventors: Frank Chang; George Tuszynski. Assignee: Temple University

Covers method of detecting early stage cancer by detection expression levels of GASP-1.


US Patent No. 8.419,916. Biological molecule separation apparatus. Inventors: Koji Sakairi; Satonari Akutsu; Atsunori Hiratsuka; Kenji Yokoyama; Yuji Maruo; Hiroshi Ohki. Assignee: Toppan Printing

Covers a system for separation of biological molecules that includes a buffer solution chamber containing a separation electrode, a separation medium, a biological molecule adsorption film and a pair of transfer electrodes.


US Patent No. 8,415,107. Thrombospondin fragments and binding agents in the detection, diagnosis and evaluation of cancer. Inventor: Kevin Williams. Assignee: W2 Holdings.

Covers the use of thrombospondin fragments in plasma for the diagnosis of cancer.


US Patent No. 8,412,464. Methods for detection and identification of cell type. Inventors: Charles Wick; Michael Stanford; Alan Zulich; Samir Deshpande; Rabih Jabbour; Jacek Dworzanski; Patrick McCubbin. Assignee: The United States of America

Covers a process for identifying cell types via identification of one or more peptide sequences.


US Patent No. 8,412,461. Systems and methods for antibody engineering. Inventors: Claes Gustafsson; Sridhar Govindarajan, Jeremy Minshull. Assignee: DNA Twopointo

Covers a system for antibody engineering in which a variant set for an antibody of interest is made by identifying a plurality of positions in the antibody and substitutions for these positions, selecting a set of these variants, then measuring the properties of these variants and the selecting a new variant set based on these measurements.


US Patent No. 8,412,460. Methods and systems for characterizing a cellular constituent using response profiles. Inventors: Roland Stoughton; Timothy Hughes. Assignee: Microsoft.

Covers methods for determining the biological function of uncharacterized genes and gene products by measuring pluralities of cellular constituents in cells with modified genes and gene products as phenotypic markers for these gene or gene products.


US Patent No. 8,410,424. Multiple ion injection in mass spectrometry. Inventors: Alexander Makarov; Oliver Lange; Stevan Horning. Assignee: Thermo Finnigan

Covers a mass spec method in which samples of two separate types of ions are accumulated in an ion store and the combined samples of these ions are then mass analyzed.

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Science Papers Examine Factors Shaping SARS-CoV-2 Spread, Give Insight Into Bacterial Evolution

In Science this week: genomic analysis points to role of human behavior in SARS-CoV-2 spread, and more.