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IP Update: Recent Patents Awarded to Thermo Fisher Scientific; Eisai; and More


Recent Patents of Interest in Proteomics

US Patent No. 8,148,677. Peptide identification and quantitation by merging MS/MS spectra. Inventors: Qiang Zhang, Roza Viner, Torsten Ueckert, Vladimir Zabrouskov. Assignee: Thermo Finnigan

Covers a method of merging spectral data from various collision fragmentation processes to provide qualitative and quantitative information on a single peptide and so provide improved identifications.

US Patent No. 8,148,676. Use of ionic matrices for MALDI mass spectrometry analysis of tissue sections. Inventors: Remi LeMaire, Isabelle Fournier, Michel Salzet, Jean-Claude Tabet. Assignees: Centre National de la Recherche Scientifique, Universite des Sciences et Technologies de Lille

Covers use of ionic MALDI matrices to study peptide or protein expression in a tissue section.

US Patent No. 8,148,169. Method and device for extracting an analyte. Inventors: Douglas Gjerde, Ronald Jones, Allen Burge. Assignee: PhyNexus

Covers extraction columns for purification of an analyte from a sample solution, including columns that employ modified pipette tips as column bodies.

US Patent No. 8,148,168. Method and device for sample preparation. Inventors: Douglas Gjerde, Allen Burge, Ronald Jones, Mark Abel. Assignee: PhyNexus

Covers extraction columns for purification of an analyte from a sample solution including columns with pore volumes of less than one microliter or 10 percent of the interstitial volume of the bed of the extraction media.

US Patent No. 8,148,094. Methods and compositions for detecting the activation state of multiple proteins in single cells. Inventors: Garry Nolan, Omar Perez. Assignee: Stanford University

Covers a method using flow cytometry to simultaneously detect the activation state of a plurality of proteins in single cells as well as screening for bioactive agents capable of modulating the activity of these proteins.

US Patent No. 8,147,847. Shigella protein antigens and methods. Inventors: Cecil Czerkinsky, Dong Wook Kim. Assignee: International Vaccine Institute

Covers Shigella protein antigens including proteins IcsP2 and SigA2 as well as antigens in common between Shigella and enteroinvasive Escherichia coli and the use of antibodies raised against these antigens for diagnostic purposes.

US Patent No. 8,143,571. Method for fractioning peptides and other compounds. Inventors: Daniel Dyer, Gary Kinsel. Assignee: Southern Illinois University

Covers a method using a polymer brush consisting of a substrate and polymer chain capable of binding a target fraction of a sample. The polymer chain can then be made to release the target fraction upon contact with a stimulus.

US Patent No. 8,143,066. Methods and apparatus for performing retention-time matching. Inventors: Marc Gorenstein, Scott Geromanos, Jeffrey Silva, Guo-Zhong Li. Assignee: Waters

Covers a method of fractionating a complex sample into multiple sample portions, each including portions of multiple polypeptides in different concentration ratios and performing LC-MS on these sample portions. Precursor ions observed via LC-MS are then associated with their corresponding polypeptides.

US Patent No. 8,142,996. Mass spectrometric determination of blood enzyme activity. Inventors: Jochen Franzen, Karsten Michelmann, Markus Kostrzewa. Assignee: Bruker

Covers use of mass spec to determine the nature and strength of enzymatic activity in blood by measuring a profile of the reaction products. The reaction is standardized by adding to the sample a standard not usually present in blood.

US Patent No. 8,137,982. Mass spectrometry precursor ion selection. Inventors: Michael May, JingWen Yao. Assignee: Shimadzu

Covers a method of selecting precursor ions from a sample polypeptide for fragmentation by mass spectrometry along with methods of determining putative amino acid sequences for that peptide.

US Patent No. 8,137,673. Nucleic acids and proteins from Streptococcus groups A & B. Inventors: John Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Herve Tettelin, Claire Fraser. Assignees: Novartis Vaccines and Diagnostics, J. Craig Venter Institute

Covers proteins from Streptococcus agalactiae and Streptococcus pyogenes that can be used for vaccines, immunogenic compositions, and diagnostics.

US Patent No. 8,131,479. Method of proteome analysis for phosphorylated protein. Inventors: Yoshiya Oda, Tsuyoshi Tabata. Assignee: Eisai

Covers a method for purifying phosphorylated protein using an immobilized metal or titania carrier as well as a method for detecting plural types of phosphorylated proteins using a database containing information on these proteins.

US Patent No. 8,129,335. Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry. Inventor: Marc Hellerstein. Assignee: University of California

Covers a mass spec-based method for measuring the kinetics of proteins or organic metabolites in living systems.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.