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IP Update: Recent Patents Awarded to Thermo Fisher, ISB, and More

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Recent Patents of Interest in Proteomics

US Patent No. 8,354,234. Mass spectrometric analysis of ligand conjugated magnetic nanoparticles. Inventors: Yu-Ju Chen; Po-Chiao Lin; Chun-Cheng Lin; Shu-Hua Chen;Po-Hung Chou; Hsin-Kai Liao. Assignee: Academia Sinica

Covers methods and systems for mass spec analysis of ligand-conjugated magnetic nanoparticles capable of screening samples for a given analyte. The invention also covers MALDI matrices composed of these nanoparticles.


US Patent No. 8,352,193. Methods for deriving a cumulative ranking. Inventors: Luke Schneider; Michael Hall; Robert Petesch. Assignee: Target Discovery

Covers a method of deriving the sequence of an oligomer like a polypeptide by determining the abundance values from mass spectrum data for the oligomer for each of a predetermined set of mass/charge values.


US Patent No. 8,349,861. Methods for identification of JAK kinase interacting molecules and for the purification of JAK kinases. Inventor: Carsten Hopf. Assignee: Cellzome

Covers immobilization compound and methods of identifying JAK interacting compounds for purification or identification of JAK.


US Patent No. 8,349,619. Method for detecting and analyzing protein interactions in vivo. Inventors: Moritz Rossner; Rico Laage; Klaus-Armin Nave; Sylvia Gruenewald. Assignee: Sygnis Bioscience

Covers methods of analyzing protein interactions in a cell by detecting recombinase or protease activity dependent on the target interaction.


US Patent No. 8,346,487. Methods of automated spectral peak detection and quantification without user input. Inventors: David Wright; Robert Grothe. Assignee: Thermo Finnigan

Covers a method of automatically identifying and characterizing spectral peaks of a spectrum by obtaining the spectrum, automatically generating a baseline-corrected spectrum, and returning data on peaks from this baseline-corrected spectrum to the user.


US Patent No. 8,343,728. Highly sensitive system and method for analysis of troponin. Inventors: Philippe Goix; Robert Puskas; John Todd; Richard Livingston; Douglas Held; Alan Wu. Assignees: Singulex; Regents of the University of California

Covers methods for the sensitive detection of cardiac troponin.


US Patent No. 8,338,579. Homogeneous analyte detection. Inventors: Thomas Adams; Edward Jablonski. Assignee: Iris Molecular Diagnostics

Covers compositions of novel binding pairs of nucleic acids that can be used for analyte detection.


US Patent No. 8,338,122. Method for determining the amino acid sequence of peptides. Inventors: Albert Heck; Shabaza Mohammed; Bastiaan Van Breukelen; Nadia Taouatas; Mihaela Drugan. Assignee: U-Protein Express

Covers a method of determining the amino acid sequence of a peptide by cleaving the peptides into proteolytic peptides with N-terminal lysine residue and dissociating the peptide precursor ions via electron transfer.


US Patent No. 8,334,503. Parallel ion parking in ion traps. Inventors: Scott Mcluckey; Paul Chrisman; Sharon Pitteri. Assignee: Purdue Research Foundation

Covers a method of controlling ion parking in an ion trap by applying a tailored waveform to inhibit simultaneously the reactions of ions of disparate m/z rations.


US Patent No. 8,329,413. Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo. Inventors: Chi-Huey Wong; Tsui-Ling Hsu; Sarah Hanson; Masaaki Sawa. Assignee: Academia Sinica

Covers methods for labeling cellular glycans bearing azide groups by addition of a fluorescent probe containing an alknyl group and for incorporating azide-containing fucose analogs into glycoconjugates.


US Patent No. 8,329,411. Diagnostic assay for Trypanosoma cruzi infection. Inventors: Rick Tarleton; Ronald Etheridge. Assignee: University of Georgia Research Foundation

Covers a multicomponent diagnostic test for infection with T cruzi, which causes Chagas disease. Also covers a method of screening for T. cruzi polypeptides to identify antigenic polypeptides that could be included in the diagnostic.


US Patent No. 8,329,408. Methods for prognosis and monitoring cancer therapy. Inventor: Scott Wilhelm. Assignee: Bayer Healthcare

Covers the use of the protein biomarkers HER-2, EGFR, VEGF, u-PA, and p-PAI-1 for cancer, particularly for patients treated with sorafenib.


US Patent No. 8,329,399. Endometrial biomarkers. Inventors: Michael Siu; Terence Colgan; Alexander Romaschin; Leroi De Souza. Assignee: NR

Covers methods of detecting endometrial diseases or an endometrial phase by measuring protein markers or the genes encoding them.


US Patent No. 8,324,569. Mass spectrometer. Inventor: Shigeki Kajihara. Assignee: Shimadzu

Covers an invention for performing mass analysis micro areas included in two-dimensional regions of a sample, dissociating specific ions into one or more product ions and subjecting these to mass analysis.


US Patent No. 8,324,347. Methods of using halogenated peptides as internal standards for liquid chromatography-mass spectrometry. Inventors: Hamid Mirzaei; Rudolf Aebersold. Assignee: Institute for Systems Biology

Covers a method of using halogenated peptides as internal standards for LC-MS, particularly in proteomic analysis.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.