Recent Patents of Interest in Proteomics
US Patent No. 8,471,201. Methods and apparatus for ion sources, ion control and ion measurement for macromolecules. Inventor: Andreas Heike. Assignee: Andreas Heike
Covers methods and systems relating to ion sources with controlled electro-pneumatic superposition, ion sources synchronized to RF multipole, ion sources with charge injection, optimized control in active feedback system, radiation supported charge-injection liquid spray, and ion sources with controlled liquid injection.
US Patent No. 8,462,339. Scanning analyzer for single molecule detection and methods of use. Inventor: Richard Livingston. Assignee: Singulex
Covers a single molecule analyzer that uses electromagnetic radiation translated through the sample to detect the presence of a single target molecule with zero carryover between samples.
US Patent No. 8,460,940. Method for analysing a complex sample by mass spectrometry. Inventors: Christoph Menzel; Christian Feckler; Udo Roth; Kerstin Steinert. Assignee: Qiagen
Covers a method using MALDI mass spectrometry for analyzing the presence of target analytes in complex samples by applying a sample to a microcrystalline MALDI matrix spot, washing it, and then analyzing it via mass spec.
US Patent No. 8,460,889. Methods and compositions for diagnosis or prognosis of cardiovascular disease. Inventors: Jay Heinecke; Tomas Vaisar; Bryan Prazen; Erik Nilsson. Assignees: University of Washington; Insilicos
Covers methods of screening subjects for cardiovascular disease or risk of cardiovascular disease using at least two biomarkers from the group consisting of apoA-I, apoA-II, apoB-100, Lp(a), apoC-I, and apoC-III, combinations or portions and/or derivatives thereof.
US Patent No. 8,457,900. Method for identification and sequencing of proteins. Inventors: Pavel Pevzner; Nuno Bandeira; Dekel Tsur. Assignee: The University of California
Covers a method of identification and sequencing of proteins in which protein samples are processed to create a mixture of modified and unmodified peptide pairs allowing correlations between MS/MS spectra of these peptide pairs to be used to reduce noise in individual MS/MS spectra, allowing for identification of peptides and modifications through fast pattern matching.
US Patent No. 8,455,818. Mass spectrometry data acquisition mode for obtaining more reliable protein quantitation. Inventors: Joshua Coon; Douglas Phanstiel; Craig Wenger, Assignee: Wisconsin Alumni Research Foundation
Covers methods for analyte quantitation via mass spec in which the amount of interference in a precursor ion isolation window is determined, allowing for reduction of interference in the subsequent MS/MS scan and improved quantitative accuracy.
US Patent No. 8,455,208. Biomarkers for follicular thyroid carcinoma and methods of use. Inventors: Stephen Hunsucker; Bryan Haugen; Mark Duncan; Romana Maier. Assignee: The University of Colorado
Covers protein biomarkers for determining whether a thyroid nodule is malignant or benign.
US Patent No. 8,455,202. Affinity selector based recognition and quantification system and method for multiple analytes in a single analysis. Inventors: Fred Regnier; Nicholas Herold; Kevin Meyer. Assignee: Perfinity Biosciences
Covers multi-dimension methods for simultaneously measuring multiple analytes in a sample solution by affinity capture of the target analytes followed by mass spec analysis.
US Patent No. 8,455,196. Biomarker for identifying subgroup of early-stage lung adenocarcinoma patients. Inventor: Jin-Mei Lai. Assignee: ND
Covers T-lymphokine-activated killer cell-originated protein kinase as a biomarker for identifying the subgroup of early-stage lung adenocarcinoma patients in early-stage non-small cell lung cancer.
US Patent No. 8,450,465. Methods of isolating peptides using surface-free affinity purification. Inventor: Calvin Wiese. Assignee: Wellspring Clinical Lab
Covers a method for combining surface-free isolation, specific competitive elution, dual epitope isolation, and protective solvents in a single column for purifying low abundance peptides for injection into a mass spectrometer.
US Patent No. 8,450,069. Highly sensitive biomarker panels. Inventors: Philippe Goix; J. Robert Puskas; John Todd; Richard Livingston; Douglas Held; Sara Le. Assignee: Singulex
Covers multi-marker immunoassays for congestive heart failure consisting of cardiac and vascular inflammation biomarkers including cTnI, BNP, IL-6, TNF.alpha, and IL-17a.
US Patent No. 8,449,748. Sample separation/adsorption appliance. Inventors: Uichi Midorikawa; Takateru Matsunaga; Yuji Maruo; Yutaka Unuma; Atsunori Hiratsuka; Hideki Kinoshita; Kenji Yokoyama.
Covers a sample separation/adsorption device consisting of two buffer solution tanks each with an electrode along with a sample separation section and conductive medium in contact with a sample adsorption member, allowing for transfer of samples.
US Patent No. 8,449,744. MS-compatible nonionic or zwitterionic surfactants in free-flow electrophoresis. Inventors: Mikkel Nissum. Assignee: Becton, Dickinson and Company
Covers use of mass spec compatible surfactants in free-flow electrophoretic methods, allowing for separation of analytes with different electrophoretic mobility.