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IP Update: Recent Patents Awarded to Life Tech; PhyNexus; and More


Recent Patents of Interest in Proteomics

US Patent No. 8,057,668. Method and device for extracting an analyte. Inventors: Douglas Gjerde, Christopher Hanna. Assignee: PhyNexus

Covers extraction columns capable of purifying a target analyte from a sample solution. The column bodies may consist of modified pipette tips in some instances and may also employ low backpressure.

US Patent No. 8,053,247. Method and device for preparing an analyte for analysis by mass spectrometry. Inventors: Isabel Feuerstein, Gunther Bonn, Douglas Gjerde, Christian Huck, Guenther Stecher. Assignee: PhyNexus

Covers a method combining column-based separation with a liquid-handling system for automated preparation of samples for analysis on a MALDI-TOF mass spectrometer.

US Patent No. 8,053,239. Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures. Inventors: Aaron Wheeler, Mais Jebrail. Assignee: The Governing Council of the University of Toronto

Covers a microfluidics-based method of extracting proteins from heterogeneous fluids via precipitation. The method can be used for a range of proteins and in complex samples such as fetal bovine serum and cell lysate.

US Patent No. 8,053,196. Clinical assays for thrombospondin fragments in the detection, diagnosis, and evaluation of cancer. Inventor: Kevin Williams. Assignee: W2 Holdings

Covers the detection of thrombospondin fragments in plasma or other bodily fluids and their use for the diagnosis of disease, primarily cancer.

US Patent No. 8,053,194. Labeling substance and chimeric substance and method for preparing the same and method for capturing, structurally analyzing and/or identifying biological substance by means of the labeling substance. Inventors: Kazuo Shinya, Tohru Natsume, Takayuki Doi. Assignee: NA

Covers use of a chimeric compound able to reversibly bind to a solid support. The compound contains a labeling portion that includes a probe capable of interacting with and identifying target molecules.

US Patent No. 8,048,638. Biomarkers of liver injury. Inventors: Stanislav Svetlov, Ronald Hayes, Ka-Wang Wang, Monika Oli. Assignee: University of Florida Research Foundation

Covers markers for diagnosing and monitoring liver injuries, including identification of several enzymes of arginine/urea/nitric oxide cycle, sulfuration enzymes, and spectrin breakdown-related products.

US Patent No. 8,044,345. Method for determining the concentration of a molecule. Inventors: Wolf Dieter Lehmann, Dominic Winter. Assignee: Deutsches Krebsforschungszentrum

Covers a method for determining the concentration of a molecule via mass spec by comparing fragment peaks from a reference sample to fragment peaks generated by the molecule of interest.

US Patent No. 8,039,227. Peptide biomarkers predictive of renal function decline and kidney disease. Inventors: Jon Klein, Michael Merchant, Grzegorz Boratyn. Assignee: University of Louisville Research Foundation

Covers a method of diagnosing kidney disease and or determining risk of kidney disease by measuring the levels of at least one peptide biomarker and comparing it to control levels.

US Patent No. 8,034,569. Methods for molecular detection. Inventors: George Jackson, Christopher Quan. Assignee: Biotex

Covers the use of DNA and RNA aptamers as molecular probes for the detection of target molecules. Includes a detection system in which such a molecular probe is paired to a reporter molecule and impairs amplification of the reporter when the target molecule is absent.

US Patent No. 8,034,223. Methods and apparatus for low resistance electrophoresis of prior-cast, hydratable separation media. Inventors: Regina Rooney, Bradley Scott, Joseph Amshey, Thomas Jackson, Sheldon Engelhorn. Assignee: Life Technologies

Covers a method and apparatus for electrophoresis using prior-cast, hydratable separation media. The method uses rehydration of this media to lodge it into a casing that establishes a voltage gradient for the electrophoretic separation of analytes.

The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.