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IP Update: Recent Patents Awarded to ISB; Novartis; and More


Recent Patents of Interest in Proteomics

US Patent No. 8,232,065. Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets. Inventors: Michael Urdea; Michael McKenna. Assignee: Tethys Bioscience

Covers methods for building diagnostic tests in biomarker data from legacy clinical sample sets, typically of low volume, using single molecule detection.

US Patent No. 8,231,768. Biosensor, biosensor chip and biosensor device. Inventors: Hiroya Ueno; Junji Nakatsuka. Assignee: Panasonic

Covers a biosensor with at least three electrodes, making it possible to assay a target substance without influence from line resistance on the working electrode side.

US Patent No. 8,231,070. Devices, methods and applications for extraction of molecules from polymeric gel electrophoretic media. Inventors: Alexander Lazarev; Thomas Rejtar; Barry Karger. Assignee: Northeastern University

Covers a device for extracting molecules from a polymeric gel by fragmenting the gel by forcing it through a deformable opening.

US Patent No. 8,227,252. Multiplex analysis of stacked transgenic protein. Inventors: John Lawry; Joshua Flook. Assignee: Dow AgroSciences

Covers use of mass spectrometry for multiplex analysis of complex protein samples from plants.

US Patent No. 8,227,251. Mass spectrum-based identification and quantitation of proteins and peptides. Inventors: Jeff Ranish; Jie Luo; Wei Yan. Assignee: Institute for Systems Biology

Covers methods for analyzing complex mixtures of proteins, particularly methods of identification and quantification of low abundance proteins using isobaric tagging.

US Patent No. 8,227,198. Methods and kits for distinguishing between specific and non-specific protein associations. Inventors: Brian Chait; Alan Tackett; Jeffrey DeGrasse; Marlene Oeffinger; Michael Rout; Matthew Sekedat. Assignee: The Rockefeller University

Covers a method of distinguishing between specific and non-specific protein interactions using a combination of tagged proteins and metabolic labeling.

US Patent No. 8,224,581. Methods for detection and identification of cell type. Inventors: Charles Wick; Michael Stanford; Alan Zulich; Samir Deshpande; Rabih Jabbour; Jacek Dworzanski; Patrick McCubbin. Assignee: The United States of America as Represented by the Secretary of the Army

Covers a process for identifying cell types in a sample by identification of peptide sequences and matching cell type to the matrices of identified peptides.

US Patent No. 8,224,579. Method of diagnosing osteoarthritis. Inventors: Reuben Gobezie; David Lee. Assignee: The Brigham and Women's Hospital

Covers methods of identifying and using protein expression profiles to diagnose osteoarthritis as well as monitoring treatment of the disease.

US Patent No. 8,222,393. Polypeptide useful for cancer diagnosis and treatment. Inventors: Tatsuhiro Yoshiki; Susumu Kageyama; Masamichi Ueda. Assignee: TSS Biotech

Covers a method for diagnosing cancer by detecting the expression of a U7 polypeptide.

US Patent No. 8,221,983. Gene products differentially expressed in cancerous cells. Inventors: Vivien Chan; Jaime Escobedo; Pablo Dominguez Garcia; Rhonda Hansen; Joerg Kaufmann; Giulia Kennedy; George Lamson; Edward Moler; Filippo Randazzo; Christoph Reinhard; Julie Sudduth-Klinger. Assignee: Novartis Vaccines and Diagnostics

Covers polypeptides that are differentially expressed in cancer cells and their uses for diagnostic and therapeutic purposes.

US Patent No. 8,221,972. Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectrometry analysis of tissue sections. Inventors: Remi Lemaire; Isabelle Fournier; Michel Salzet; Michel Dechamps; Jean-Claude Tabet; Gottfried Proess; Ivo Rudloff; Marc Lemaitre. Assignees: Centre National de la Recherche Scientifique; Universite des Sciences et Technologies de Lille; Eurogentec

Covers a system of molecular tags, cleavable linkers, and affinity molecules that bind to target molecules that can be used for mass spec-based analysis of tissues.

US Patent No. 8,221,762. Naturally processed measles virus peptides from class II HLA molecules. Inventors: Gregory Poland; Inna Ovsyannikova; David Muddiman; Kenneth Johnson. Assignee: Mayo Foundation for Medical Education and Research

Covers a preparation of peptides from class II HLA molecules and their use in vaccines for the disease as well as markers of the disease.

US Patent No. 8,221,604. Method for controlling substance transfer. Inventors: Kazuyoshi Yano; Isao Karube; Atsunori Hiratsuka; Shuo-Wen Tsai. Assignee: Katayanagi Institute

Covers a method of transferring fluids and substances contained in fluids by using a separation medium to control transfer of the substance from an initial cavity to a second cavity, enabling applications including chip-based two-dimensional electrophoresis.

US Patent No. 8,219,325. Method for determining the ratio of two distinct peptides or polynucleic acids. Inventor: Wolf Dieter Lehmann. Assignee: DKFZ Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Covers a method of determining the ratio of two target peptides by using peptide standards, detecting the signals of the targets and standards in an analyzer, and calculating the ratio of the target peptides based on the measured ratios of the standards.

US Patent No. 8,218,878. Cumulative time-resolved emission two-dimensional gel electrophoresis. Inventor: Asa Wheelock. Assignee: HiKari Bio

Covers a method of gel electrophoresis that uses differences in fluorescent lifetime imaging to distinguish between labeled proteins and non-specific background to improve sensitivity and dynamic range.

US Patent No. 8,216,789. Diagnostic panel of cancer antibodies and methods for use. Inventor: Mary Disis; Vivian Goodell; Hailing Lu. Assignee: University of Washington

Covers a method for detection of cancer by incubating a specimen with antigens and detecting the presence or absence of immunocomplexes formed between the antigens and antibodies in the specimen.

US Patent No. 8,216,778. Methods of measuring cell viability in tissue engineered products. Inventor: Yongzhong Wang. Assignee: Genzyme

Covers a method of measuring the viability of cultured cells by detecting cell-death stable proteins or enzyme activities.

US Patent No. 8,211,693. Device for separating and/or analyzing several molecular targets dissolved in a complex mixture. Inventors: Nicolas Ugolin; Sylvie Chevillard; Catherine Ory; Jerome Lebeau. Assignee: Commissariat a l'Energie Atomique

Covers a device for separating molecular targets in complex mixtures that consists of a matrix of micro-columns with each column comprising an immobilized molecular probe for a particular target.

US Patent No. 8,211,630. Diagnostic agent and therapeutic agent for pancreatic cancer. Inventors: Hiroyuki Aburatani; Hiroko Iwanari; Isao Kohno. Assignees: Perseus Proteomics; University of Tokyo

Covers diagnosis and treatment of pancreatic cancer using an anti-AMIGO2 antibody.

US Patent No. 8,209,132. Methods and products related to the improved analysis of carbohydrates. Inventors: Carlos Bosques; Nishla Keiser; Aravind Srinivasan; Rahul Raman; Karthik Viswanathan; Ram Sasisekharan; Pankaj Gandhe; Sasi Raguram. Assignees: Momenta Pharmaceuticals; Massachusetts Institute of Technology

Covers methods of analysis of glycosylation patterns on cells, tissue, and bodily fluids and the use of data from that analysis in developing diagnostic and treatment methods.

US Patent No. 8,206,942. Methods of identifying LRRK2 inhibitors. Inventors: Dario Alessi; Jeremy Nichols. Assignee: Medical Research Council

Covers a method of identifying compounds capable of modulating LRRK2 protein kinase activity on a substrate polypeptide.

US Patent No. 8,206,939. Methods and compositions for risk stratification. Inventors: Omar Perez; Garry Nolan; Jonathan Irish. Assignee: The Board of Trustees of the Leland Stanford Junior University

Covers a technique for simultaneously determining the activation states of a plurality of proteins in single cells and the identification of cellular subsets exhibiting different activation states in a complex cell population.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.