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IP Update: Recent Patents Awarded to Insilicos, University of California, and More


Recent Patents of Interest in Proteomics

US Patent No. 8,258,465. Mass spectrometry apparatus. Inventor: Mayumi Matsui. Assignee: Shimadzu

Covers a mass spectrometry device that allows users to define upper and lower limit values for peak sorting and exclude peaks outside the defined intensity range while selecting the remaining peaks for MS2 analysis.

US Patent No. 8,257,917. Salivary biomarkers for Sjogren's syndrome. Inventors: David Wong; Shen Hu; Jianghua Wang. Assignee: The Regents of the University of California

Covers salivary protein and RNA factors that can be used for the diagnosis and prognosis of Sjogren's syndrome.

US Patent No. 8,252,913. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics. Inventors: Robert Schaub; Kathleen McGinness; Jennifer Nelson; Ryan Genga; Emily Waters; Jeffrey Kurz; John Diener. Assignee: Baxter Healthcare

Covers aptamers that bind to TFPI and their use as therapeutics and diagnostics of bleeding disorders and other diseases in which the protein has been implicated.

US Patent No. 8,247,181. Borrelia diagnostics and screening methods. Inventors: Alan Barbour; Philip Felgner. Assignee: The Regents of the University of California

Covers methods of detecting Borrelia proteins and antibodies to these proteins to detect patient exposure to the bacteria.

US Patent No. 8,246,832. Fluidics device. Inventors: Lee Lomas; Jian Ding; Egisto Boschetti. Assignee: Bio-Rad

Covers a method for separating samples into a desired number of sub-samples by passing it through a number of separation media by using conduits to route fluids through this media.

US Patent No. 8,244,484. Proteome epitope tags and methods of use thereof in protein modification analysis. Inventors: Frank Lee; Xun Meng; Noubar Afeyan. Assignee: EMD Millipore

Covers methods for detecting proteins in a sample by using capture agents that interact with sequences unique to a protein or set of proteins. Also covers the method in array form.

US Patent No. 8,241,894. Method for analyzing proteins. Inventors: Thomas Joos; Dieter Stoll. Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universitat Tubingen

Covers a method of analyzing proteins using an array of capture molecules specific for peptide epitopes, which can be used to analyze protein mixtures that have been digested to peptide fragments.

US Patent No. 8,241,893. Method and device for separating molecular targets in a complex mixture. Inventors: Nicolas Ugolin; Sylvie Chevillard; Alexandre Coutant; Jerome LeBeau. Assignee: Commissariat a l 'Energie Atomique

Covers a method of analyzing molecules in a complex mixture by bring the mixture into contact with an array of primary probes, recovering the probes and targets bound in a probe/target complex, and then quantitatively analyzing these recovered complexes.

US Patent No. 8,241,861. Methods and compositions for diagnosis or prognosis of cardiovascular disease. Inventors: Jay Heinecke; Tomas Vaisar; Bryan Prazen; Erik Nilsson. Assignee: Insilicos

Covers the detection of biomarkers in an HDL subfraction or complex containing apoA-I or apoA-II and comparing measurements of these markers to reference standards in order to diagnose cardiovascular disease.

US Patent No. 8,236,574. Ultra-sensitive detection of molecules or particles using beads or other capture objects. Inventors: David Duffy; David Rissin; David Walt; David Fournier; Cheuk Kan. Assignee: Quanterix

Covers a system for detecting and quantifying analytes in a fluid sample using capture objects spatially separated into a number of reaction vessels.

US Patent No. 8,236,487. Tumor specific oligosaccharide sequences and use thereof. Inventors: Jari Natunen; Susann Teneberg; Karl-Anders Karlsson; Tero Satomaa; Annamari Heiskanen. Assignee: Glykos Finland Oy

Covers oligosaccharide sequences specifically expressed by human tumors and a method of determining the presence of these sequences in biological samples to detect cancer.

US Patent No. 8,232,073. Quantification of non-reducing end glycan residual compounds. Inventors: Brett Crawford; Jillian Brown; Charles Glass; Jim Beitel; Robin Jackman. Assignee: Zacharon Pharmaceuticals

Covers methods of quantifying glycan levels to diagnose or monitor disorders associated with abnormal glycan accumulation.

The Scan

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.

Adenine Base Editor Targets SCID Mutation in New Study

Researchers from the University of California, Los Angeles, report in Cell that adenine base editing was able to produce functional T lymphocytes in a model of severe combined immune deficiency.

Researchers Find Gene Affecting Alkaline Sensitivity in Plants

Researchers from the Chinese Academy of Science have found a locus affecting alkaline-salinity sensitivity, which could aid in efforts to improve crop productivity, as they report in Science.

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.