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IP Update: Recent Patents Awarded to IBM, Biomerieux, and More

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Recent Patents of Interest in Proteomics

US Patent No. 8,372,655. Plate for mass spectrometry, process for preparing the same and use thereof. Inventors: Kenji Tanaka; Lyang-ja Lee; Koji Munechika; Hisashi Arikuni; Bungo Ochiai. Assignee: Protosera

Covers a plate for mass spectrometry that can be prepared with a layer of PVDF and blotted with sample prepared via gel electrophoresis.


US Patent No. 8,372,288. Precision peak matching in liquid chromatography-mass spectroscopy. Inventors: Peicheng Du; Frank Suits. Assignee: International Business Machines

Covers a method for identifying common peaks among unidentified peaks in different LC-MS runs, to allow for extracting peptide IDs from disparate LC-MS databases.


US Patent No. 8,367,830. Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins. Inventors: Kathryn Bell; Nigel Ramsden; Giovanna Bergamini Moore; Gitte Neubauer. Assignee: Cellzome

Covers immobilization compounds that can be used for identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins.


US Patent No. 8,367,806. Protein disulfide isomerase assay method for the in vitro diagnosis of colorectal cancer. Inventors: Yasemin Ataman-Onal; Corinne Beaulieu; Sandrine Busseret; Jean-Philippe Charrier; Genevieve Choquet-Kastylevsky; Dominique Rolland. Assignee: Biomérieux

Covers a method for diagnosis of colorectal cancer by measuring protein disulfide isomerase tumor marker in a biological sample using anti-PDI antibodies.


US Patent No. 8,367,588. Selective posttranslational modification of phage-displayed polypeptides. Inventors: Meng-Lin Tsao; Feng Tian; Peter Schultz. Assignee: The Scripps Research Institute

Covers a method of incorporating unnatural amino acids into phage-displayed polypeptides, providing targets for adding posttranslational modifications.


US Patent No. 8,367,366. Methods and kits for quantitative methyltransferase and demethylase measurements. Inventors: Alan Tackett; Nathan Avaritt; Lauren Blair. Assignee: The Board of Trustees of the University of Arkansas

Covers methods and kits for characterizing the activity of a methyltransferase or demethylase by enzymatically methylating or demethylating a peptide fragment then non-enzymatically methylating the peptide with methyl groups with differing molecular weights and characterizing the peptide via mass spectrometry.


US Patent No. 8,367,362. Aminoacylase 1 assay method for the in vitro diagnosis of colorectal cancer. Inventors: Jean-Philippe Charrier; Genevieve Choquet-Kastylevsky; Dominique Rolland. Assignee: Biomérieux

Covers a method for the diagnosis, screening, therapeutic monitoring, and prognosis of colorectal cancer by measuring the aminoacylase 1 tumor marker either by mass spectrometry or biochemical means.


US Patent No. 8,367,360. Method of screening for inhibitors of tau protein phosphorylation by tyrosine kinase c-Abl. Inventors: Malcolm Ward; Helen Byers; Brian Anderton; Pascal Derkinderen; Christopher Reynolds; Ritchie Williamson. Assignees: Proteome Sciences; King's College London

Covers methods of screening candidate compounds useful in treating Alzheimer's disease by inhibiting phosphorylation of tau protein by tyrosine kinase c-Abl.


US Patent No. 8,367,198. Precisely-shaped porous particles. Inventors: Peter Wickert; Scott Culler; Jerald Rasmussen. Assignee: 3M Innovative Properties

Covers methods for making composites consisting of a plurality of discrete, precisely shaped particles with porosities and at least one flat side. The particles can be used for chromatography.


US Patent No. 8,362,417. Mass spectrometry assay for plasma-renin. Inventors: Cory Bystrom; Richard Reitz; Nigel Clarke. Assignee: Quest Diagnostics

Covers an assay for measuring renin activity in plasma using mass spectrometry by detecting the amount of angiotensin 1 present in the sample.


US Patent No. 8,362,219. Open channel solid phase extraction systems and methods. Inventors: Douglas Gjerde; Christopher Hanna. Assignee: PhyNexus

Covers a method of extracting analytes such as proteins from a solution by passing the solution through an extraction channel containing a solid phase extraction surface and then eluting the analyte.


US Patent No. 8,361,806. Open channel solid phase extraction systems and methods. Inventors: Douglas Gjerde; Christopher Hanna. Assignee: PhyNexus

Covers a method of using solid phase extraction channels to prepare native and non-denatured biomolecules, and especially for purification, concentration, and analysis of proteins.


US Patent No. 8,361,740. Peptide standards. Inventors: Charles Turner; Raymond Dalton. Assignee: King's College London

Covers methods for making peptide standards for mass spectrometry by identifying peptide sequence and cleavage sites of interest, adding C-terminal extensions to these sequences, and synthesizing these extended peptides.


US Patent No. 8,361,731. Ezrin assay method for the in vitro diagnosis of colorectal cancer. Inventors: Monique Arpin; Yasmin Ataman-Onal; Corinne Beaulieu; Sandrine Busseret; Jean-Philippe Charrier; Genevieve Choquet-Kastylevsky; Dominique Rolland. Assignee: Biomérieux

Covers method of diagnosing colorectal cancer by detecting the Ezrin protein marker in a sample using an anti-Ezrin antibody.


US Patent No. 8,357,532. Expanding the eukaryotic genetic code. Inventors: Jason Chin; Ashton Cropp; Christopher Anderson; Peter Schultz. Assignee: The Scripps Research Institute

Covers methods for introducing translational components such as orthogonal tRNAs to encode unnatural amino acids in eukaryotic cells and to produce proteins containing these unnatural amino acids.


US Patent No. 8,357,497. Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets. Inventors: Michael Urdea; Michael McKenna; Assignee: Tethys Bioscience

Covers methods for developing diagnostic tests using biomarker information obtained from legacy clinical sample sets via single molecule detection techniques.

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.