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IP Update: Recent Patents Awarded to Caris, Ventana, and More

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Recent Patents of Interest in Proteomics

US Patent No. 8,729,464. Method for determining stage of chronic kidney disease, device therefor and method for operating the same. Inventors: Noriaki Tanaka; Masahiro Kohno; Emiko Sato; Kouichi Fujiwara. Assignee: Noriaki Tanaka

Covers markers including protein markers for determining the stage of chronic kidney disease.


US Patent No. 8,729,241. Characterization of O-linked glycans. Inventors: Cuihua Liu; Xiao-Jin Xu; Shiming Dong; Guy Dellorusso. Assignee: Momenta Pharmaceuticals

Covers methods for analyzing O-linked glycans including subjecting glycoproteins to preparations that release the N-glycan followed by the O-glycan.


US Patent No. 8,728,980. Peptide microarray and method of use. Inventors: Wei Wang; Zheng Xu. Assignee: University of California

Covers synthetic peptide arrays for uses including measurement of protein-peptide interactions, epitope mapping, and drug screening.


US Patent No. 8,728,744. Salivary protein biomarkers for human oral cancer. Inventors: Shen Hu; David Wong. Assignee: University of California.

Covers protein biomarkers for distinguishing between oral cancer and periodontal disease as well as for providing prognoses for the two conditions.


US Patent No. 8,715,926. Biomarkers for the detection of head and neck tumors. Inventors: Penelope Duerksen-Hughes; Maria Filippova; Valeri Filippov. Assignee: Loma Linda University

Covers proteins markers for detecting human papilloma virus and head and neck tumors.


US Patent No. 8,712,695. Method, system, and computer program product for scoring theoretical peptides. Inventors: Ignat Shilov; Sean Seymour; Ron Bonner; Alpesh Patel. Assignee: DH Technologies Development

Covers a method of scoring peptide matches that uses sequence tags to focus computing resources on searching the regions of a protein database most likely to yield a correct identification.


US Patent No. 8,710,429. Identification of biomarkers in biological samples and methods of using same. Inventors: Jay Hanas; James Hocker; Daniel Brackett; Russell Postier; Marvin Peyton; John Cheung. Assignee: University of Oklahoma

Covers methods including electrospray time-of-flight mass spectrometry for identifying protein biomarkers in liquid samples.


US Patent No. 8,709,732. Biomarkers of gastric cancer and use thereof. Inventors: Samuel Lo; Katie Lam. Assignee: The Hong Kong Polytechnic University

Covers protein biomarkers including albumin, T-kininogen I, alpha-2-HS glycoprotein, alpha-1-antitrypsin, afamin, gamma-actin, stress 70 protein, apolipoprotein A-I, apolipoprotein A-IV, transthyretin, and murinoglobulin for early detection of gastric cancer.


US Patent No. 8,709,224. Methods for the detection of biologically relevant molecules and their interaction characteristics. Inventor: Christopher Atwood. Asssigne: NA

Covers a method of detecting molecules by concentrating them into holes in a sheet of chemically inert material and measuring levels of electric current through the holes or the fluorescence near the hole openings. Molecules can be identified by collecting the population of the holes and inserting them into a mass spectrometer.


US Patent No. 8,704,164. Mass analysis using alternating fragmentation modes. Inventor: Robert Bateman. Assignee: Micromass UK Limited

Covers a method of mass spectrometry in which electron capture dissociation fragmentation is switched back and forth between a high-fragmentation mode and a low-fragmentation mode.


US Patent No. 8,703,903. Method for quantification of allergens. Inventor: Ulla Seppala. Assignee: ALK-Abello.

Covers a method of measuring the amount of allergen in a sample by degrading the sample to obtain a mixture of peptides and then using mass spec analysis to compare the quantity of allergen peptides in the sample to a reference sample.


US Patent No. 8,703,435. Peptide biomarkers of cardiovascular disease. Inventors: Jon Klein; Michael Merchant; Rosemary Ouseph; Richard Ward. Assignee: University of Louisville

Covers peptide biomarkers for diagnosing cardiovascular disease as well as for determining the efficacy of treatment or tracking progression of the disease.


US Patent No. 8,703,433. Marker for amyotrophic lateral sclerosis, and use thereof. Inventors: Hideaki Hara; Masamitsu Shimazawa; Hirotaka Tanaka. Assignee: Hideaki Hara

Covers a biomarker for ALS containing a transmembrane glycoprotein nmb.


US Patent No. 8,703,417. Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest. Inventors: Christopher Bieniarz; Michael Farrell. Assignee: Ventana Medical Systems

Covers a method of detecting analytes of interested by binding an enzyme-labeled conjugate molecule to an analyte of interest in the presence of a redox-inactive reductive species and a soluble metal ion. The enzyme catalyzes the conversion of the inactive reductive species to an active reducing agent, which reduces the metal ion to a metal atom and allows for detecting the analyte base on deposition of the metal.


US Patent No. 8,702,950. Device for electrophoresis, device for transfer, device for electrophoresis and transfer, chip for electrophoresis and transfer, and method for electrophoresis, method for transfer, and method for electrophoresis and transfer. Inventors: Yuji Maruo; Yutaka Unuma; Atsunori Hiratsuka; Hideki Kinoshita; Kenji Yokoyama; Koji Sakairi; Satonari Akutsu. Assignees: Sharp Kabushiki Kaisha; Toppan Printing

Covers an electrophoresis device that uses a plurality of electric conductors to prevent decline in electrophoresis speed. The different electrode regions are insulated from each other and arranged in a specific direction.


US Patent No. 8,700,335. System and method for determining individualized medical intervention for a disease state. Inventors: Daniel Von Hoff; Robert Penny. Assignee: Caris MPI.

Covers a method for determining individualized medical interventions for a particular disease state – especially cancers – using molecular profiling from the patient, including data on gene and protein expression.


US Patent No. 8,697,604. Labeling agents for mass spectrometry comprising tertiary amines. Inventors: Christian Hamon; Karsten Kuhn; Andrew Thompson; Dieter Reuschling; Juergen Schaefer. Assignee: Electrophoresis Limited

Covers a method of labeling peptides for mass spec analysis with a mass tag reagent comprising a reactive functionality capable of reacting with an amino group, and a tertiary amino group linked to the reactive functionality.


US Patent No. 8,697,367. Markers for detection of complications resulting from in utero encounters. Inventors: Catalin Buhimschi; Irina Buhimschi; Vineet Bhandari. Assignee: Yale University

Covers biomarkers including protein biomarkers for predicting and diagnosing complications that can lead to premature birth.


US Patent No. 8,692,187. Electron transfer dissociation for biopolymer sequence analysis. Inventors: Donald Hunt; Joshua Coon; John Syka; Jarod Marto. Assignee: University of Virginia.

Covers a method of fragmenting ions in a mass spectrometer by electron transfer dissociation and using this fragmentation for sequence analysis of peptides and proteins.


US Patent No. 8,691,088. Narrow I.D. monolithic capillary columns for high efficiency separation and high sensitivity analysis of biomolecules. Inventors: Alexander Ivanov; Li Zang; Barry Karger. Assignee: Northeastern University

Covers a method of preparing ultra-nanoscale-LC monolithic separation medium for use in capillary columns or microchip channels.

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.