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IP Update: Recent Patents Awarded to Bruker, Stanford, and More

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Recent Patents of Interest in Proteomics

US Patent No. 8,401,800. Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity. Inventor: Marc Hellerstein. Assignee: University of California

Covers a method of measuring molecular flux rates within biomolecular processes involved in disease pathogenesis and comparing them between subjects and controls to obtain information on drug efficacy or toxicity.


US Patent No. 8,399,830. Means and method for field asymmetric ion mobility spectrometry combined with mass spectrometry. Inventors: Andrew Park; Andrew Kaplan; Mark Ridgeway; Gary Glish. Assignee: Bruker Daltonics; University of North Carolina at Chapel Hill

Covers a method for combining field asymmetric ion mobility spectrometry (FAIMS) with mass spectrometry by creating smooth geometric transitions between the channel in the FAIMS analyzer and the channel in the capillary leading to the mass analyzer.


US Patent No. 8,399,827. Mass spectrometry systems. Inventor: Robert Grothe. Assignee: Cedars-Sinai Medical Center

Covers methods related to mass spectrometry systems such as calibration methods and methods for identification of peptides and proteins including a phase-modeling analysis technique.


US Patent No. 8,399,402. Polypeptide as standard for proteome analysis. Inventors: Robert Beynon; Simon Gaskell; Julie Pratt; Claire Eyers. Assignee: Polyquant

Covers a polypeptide for use as a standard in mass spec-based peptide analysis where the analysis consists of at least 16 peptides selected from an established group of peptides along with an artificial protein comprising the polypeptide.


US Patent No. 8,399,383. Protein chips for high throughput screening of protein activity. Inventors: Michael Snyder; Mark Reed; Heng Zhu; James Klemic. Assignee: Yale University.

Covers the creation of protein chips containing densely packed reaction wells for large-scale studies of protein function as well as methods of the using the chips to assay the presence, amount, or function of proteins present in a sample.


US Patent No. 8,399,260. Method for concentration of low-molecular-weight proteins and peptides in body fluid sample. Inventors: Yoshio Kodera; Tadakazu Maeda; Yusuke Kawashima. Assignee: School Juridical Person Kitasato Institute

Covers a method for extracting low molecular weight proteins from serum or plasma.


US Patent No. 8,399,203. Analysis of chemically crosslinked cellular samples. Inventors: Bathsheba Chong; Patrick Parks. Assignee: 3M

Covers a method of analyzing chemically crosslinked analytes, typically using mass spectrometry.


US Patent No. 8,394,639. Biomarkers for renal disease. Inventors: Hassan Dihazi; Gerhard Muller; Frank Strutz. Assignee: University Medical Center Göttingen

Covers methods and kits of diagnosing renal disease or predicting risk of renal disease by determining the levels of a ubiquitin fragment with a given mass-to-charge ratio or the levels of a nucleic acid encoding that fragment.


US Patent No. 8,394,601. Peptide biomarkers predictive of renal function decline and kidney disease. Inventors: Jon Klein; Michael Merchant; Grzegorz Boratyn. Assignee: University of Louisville

Covers a method of diagnosing kidney disease or predicting a patient's risk of kidney disease based on levels of at least one peptide biomarker.


US Patent No. 8,394,599. Methods and compositions for risk stratification. Inventors: Omar Perez; Garry Nolan; Jonathan Irish. Assignee: Stanford University

Covers a method for simultaneous determination of the activation states of a plurality of proteins in single cells.


US Patent No. 8,389,222. Apolipoprotein fingerprinting technique and methods related thereto. Inventors: Emelita Breyer; Mary Robinson. Assignees: Emelita Breyer; Sean Breyer

Covers a method for determining the concentrations and modifications of apolipoprotein in a patient sample by pulling out the target protein via antibody chip and analyzing it via mass spectrometry.


US Patent No. 8,383,425. Method and compositions for the detection of protein glycosylation. Inventors: Linda Hsieh-Wilson; Nelly Khidekel; Hwan-Ching Tai; Sabine Arndt. Assignee: California Institute of Technology

Covers a method of detecting O-GlcNAc posttranslational modifications on proteins by selectively transferring ketone functionality onto thusly modified proteins, which can then be pulled down via biotin tagging.


US Patent No. 8,382,987. Method for harvesting nanoparticles and sequestering biomarkers. Inventors: Alessandra Luchini; Lance Liotta; Emanuel Petricoin; Barney Bishop; Francesco Meani; Claudia Fredolini; Thomas Dunlap; Alexis Patanarut. Assignee: Not provided

Covers capture particles made of a polymeric matrix having alterable pore sizes that allow for target analytes to enter and then be subsequently trapped, enabling researchers to isolate and identify target analytes and concentrate them for analysis.

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.