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IP Update: Recent Patents Awarded to Bruker; BRAHMS; and More


Recent Patents of Interest in Proteomics

US Patent No. 8,202,735. Methods for screening cells and antibodies. Inventors: Christine Genick, Lance Laing; Peter Li; Timothy Smith; Lara Madison; William Karl; Bo Lin. Assignee: X-Body

Covers methods for screening antibodies and detecting specific binding of an antibody to a protein or cell.

US Patent No. 8,202,510. Biomarkers for amyotrophic lateral sclerosis. Inventors: Robert Bowser; Srikanth Ranganathan. Assignee: University of Pittsburgh

Covers a method of diagnosing amyotrophic lateral sclerosis as well as monitoring the effectiveness of drug therapies for the disease and determining the site of onset by analyzing protein biomarkers via mass spectrometry.

US Patent No. 8,198,038. Plasma biomarker tool for the diagnosis of liver cancer comprising liver carboxylesterase 1 and liver cancer screening method. Inventors: Young-Ki Paik; Keun Na. Assignee: Industry-Academic Cooperation Foundation, Yonsei University

Covers a plasma protein biomarker for diagnosing hepatocellular carcinoma by measuring it in plasma using a combination of 2D gel electrophoresis and mass spectrometry.

US Patent Nos. 8,197,758 and 8,197,759. Zwitterionic dyes for labeling in proteomic and other biological analyses. Inventors: Edward Dratz; Paul Grieco. Assignee: Montana State University.

Both patents cover zwitterionic dyes for labeling and identifying proteins. Dyes are non-titratable and maintain their zwitterionic character over a broad pH range.

US Patent No. 8,188,424. Preparative ion mobility spectrometry. Inventors: Gokhan Baykut; Jonas Bergquist. Assignee: Bruker Daltonik

Covers an ion mobility spectrometer for generating and separating ions that can be used as a stand-alone instrument or part of a hybrid analysis instrument.

US Patent No. 8,187,893. Mass spectrometric based assay for presence of a protein without the use of a standard. Inventor: Christie Hunter. Assignee: DH Technologies Development

Covers development of mass spec assays using parent-daughter ion transition monitoring to allow for measurement of a protein in a sample without use of a standard.

US Patent No. 8,187,889. Protein markers for the diagnosis and prognosis of ovarian and breast cancer. Inventors: Marta Lomnytska; Anna Dubrovska; Ulf Hellman; Nataliya Volodko; Serhiy Souchelnytskyi. Assignee: Ludwig Institute for Cancer Research

Covers use of the proteins cSHMT, Tbx3, and utrophin in plasma to detect and monitor the progression of ovarian and breast cancer.

US Patent No. 8,187,827. Diagnostic methods for acute ischemic disease using activated hepcidin as an indicator. Inventor: Naohisa Tomosugi. Assignee: NA

Covers use of serum hepcidin-20 levels for early diagnosis of acute ischemic diseases.

US Patent No. 8,183,004. Determination of short-chain SRL alcohol dehydrogenase (DHRS4) as a biomarker for inflammations and infections. Inventor: Andreas Bergmann; Joachim Struck; Monika Uhlein. Assignee: BRAHMS

Covers us of DHRS4 as a biomarker for the detection and prognosis of septic inflammations and infections.

US Patent No. 8,183,000. Diagnosis of liver pathology through assessment of protein glycosylation. Inventor: Timothy Block; Mary Ann Comunale; Anand Mehta. Assignee: Philadelphia Health & Education Corporation

Covers use of lectin protein binding analysis to diagnose liver pathologies.

US Patent No. 8,182,998. Blood biomarkers for bone fracture and cartilage injury. Inventor: Lovorka Grgurevic; Boris Macek; Slobodan Vukicevic. Assignee: Genera Istrazivanja

Covers blood biomarkers and their use for determining whether a person has sustained a bone fracture or cartilage injury.

US Patent No. 8,182,746. Electrophoresis process using a valve system. Inventor: Norberto Guzman. Assignee: Princeton Biochemicals

Covers an electrophoresis system composed of a large transport capillary intersecting with multiple smaller separation capillaries, allowing for the performance of two or more dimensions of separation.

US Patent No. 8,178,834. Ion detection and parameter estimation for N-dimensional data. Inventor: Marc Gorenstein; Guo-Zhong Li. Assignee: Waters

Covers methods and materials for mass spec analysis obtaining noisy data from a sample, convolving that data with an artifact-reducing filter, and locating ion peaks in the convolved data.

US Patent No. 8,178,320. Artificial antibody library with super-repertory. Inventors: Nobuyoshi Shimizu; Atsushi Takayanagi; Michiyo Okui. Assignee: Keio University

Covers construction of an artificial antibody library using a cDNA library as a template and manipulating the VH and VL regions of the immunoglobulin gene.

US Patent No. 8,178,316. Evaluating proteins. Inventors: Joshua Labaer; Niroshan Ramachandran; Manuel Garcia. Assignee: President and Fellows of Harvard College

Covers a substrate that includes a nucleic acid coding for a test amino acid sequence and an affinity tag; and a binding agent that recognizes this affinity tag. Contacting the substrate with a translation effector translates this hybrid sequence; the binding agent then binds this hybrid sequence, removing the nucleic acid.

US Patent No. 8,173,393. Expanding the eukaryotic genetic code. Inventors: Jason Chin; Ashton Cropp; Christopher Anderson; Peter Schultz. Assignee: The Scripps Research Institute

Covers methods using tRNAs to produce proteins with unnatural amino acids.

The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.