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IP Update: Recent Patents Awarded to BG Medicine; Proxeon; and More


Recent Patents of Interest in Proteomics

US Patent No. 8,080,786. Mass spectrometer. Inventors: Takashi Baba, Hiroyuki Satake, Izumi Waki. Assignee: Hitachi High-Technologies

Covers a linear ion trap mass spectrometer capable of implementing electron capture dissociation and collision dissociation.

US Patent No. 8,080,784. Ionization device. Inventors: Qiao Liang, Pengyuan Yang, Baohong Liu, Niels Lion, Christophe Roussel, Hubert Girault. Assignee: École Polytechnique Fédérale de Lausanne

Covers a plate for MALDI mass spec that consists of an electrically conductive substrate covered with a light sensitive matrix that oxidizes a probe molecule when irradiated with light.

US Patent No. 8,075,854. Microfluidic chips for rapid multiplex ELISA. Inventors: Shang-Tian Yang, Yunling Bai, Wei-Cho Huang. Assignees: The Ohio State University Research Foundation, Bioprocessing Innovative Company

Covers a microfluidic chip comprising channels including tortuous path sections where receptors for the detection of target analytes can be immobilized. It is intended especially for immunoassays like ELISAs.

US Patent No. 8,074,494. Plugged flow 2D chromatography. Inventors: Ole Vorm, Michael Barrett Andersen, Ole Sorensen, Soren Theodorsen. Assignee: Proxeon Biosystems

Covers a split-free nano-flow liquid chromatography device that consists of multiple columns connected in series as well as an autosampler for injecting samples.

US Patent No. 8,071,721. Antigens and antibodies associated to pancreatic ductal adenocarcinoma. Inventors: Francesco Novelli, Barbara Tomaino, Paola Cappello. Assignees: Ribovax Biotechnologies, Bioline Diagnostici

Covers the use of human protein antigens and related antibodies – phosphorylated isoforms of alpha-enolase, in particular – to diagnose and treat pancreatic ductal adenocarcinoma and similar cancers.

US Patent No. 8,071,392. Mass spectrometric analysis of proteins using stable isotopes of pyrylium derivates as labels. Inventor: Shigeru Matsukawa. Assignees: National University Corporation University of Fukui, Taiyo Nippon Sanso Corporation

Covers a method using two or more stable isotopes of a compound to produce a difference in the mass of proteins in samples being analyzed by mass spec.

US Patent No. 8,068,990. Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids. Inventor: Ron Rosenfeld, Srinivasa Nagalla, Mike Gravett. Assignee: Hologic

Covers the use of comprehensive proteomic analyses of human amniotic fluid and cervical vaginal fluid to correlate changes in the normal proteome with various disease conditions including intra-amniotic infection, pre-term labor, and chromosome defects.

US Patent No. 8,068,987. Method and system for profiling biological systems. Inventors: Noubar Afeyan, Jan van der Greef, Frederick Regnier, Aram Adourian, Eric Neumann, Matej Oresic, Robbert Verheij. Assignee: BG Medicine

Covers methods and systems for building biological profiles based on similarities, differences, and correlations between biomolecular components of a plurality of biological samples.

US Patent No. 8,067,241. Method and apparatus for antigen retrieval process. Inventors: Michael Gerdes, Anup Sood, Christopher Sevinsky. Assignee: General Electric

Covers a method for retrieving antigens from formaldehyde-fixed tissue by incubating the sample in several different antigen retrieval solutions at several different temperature points.

US Patent No. 8,067,198. Protein expression system. Inventors: John Hesketh, Hanne Ravneberg, Christine Gjerdrum, Albert Tauler, Ian Pryme, Beate Stern. Assignee: Prolume

Covers a method of producing proteins via host cells containing nucleic acids encoding chimeric proteins comprising a signal peptide and the target protein.

US Patent No. 8,067,152. Liver cancer biomarkers. Inventor: Laura Beretta. Assignee: The Fred Hutchinson Cancer Research Center

Covers protein biomarkers including calreticulin, calreticulin precursor, and PDIA3 for diagnosing liver cancer or determining risk of developing liver cancer.

US Patent No. 8,062,492. Method for analyzing protein. Inventor: Yoshio Suzuki, Kenji Yokoyama, Ichiji Namatame. Assignees: Sharp Kabushiki Kaisha, Toppan Printing, Katayanagi Institute

Covers a method of analyzing proteins by electrophoresis using labeling compounds and then detecting a complex of these compounds and the target protein via spectrophotometrical measurement.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.