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IP Update: Recent Patents Awarded to AB Sciex, Vermillion, and More

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Recent Patents of Interest in Proteomics

US Patent No. 8,686,350. Multiple ion injection in mass spectrometry. Inventors: Alexander Makarov; Oliver Lange; Stevan Horning. Assignee: Thermo Finnigan

Covers a method of mass spectrometry in which types of ions are accumulated to be analyzed in combination and accumulation is done so as to achieve a target number of ions based on the result of previous measurements.


US Patent No. 8,685,755. Combinatorial multidomain mesoporous chips and a method for fractionation, stabilization, and storage of biomolecules. Inventors: Mauro Ferrari; Xuewu Liu; Ennio Tasciotti; Ali Bouamrani; Ye Hu. Assignee: The University of Texas

Covers a fractionation device based on multidomain mesoporous chips that can be used for capturing and enriching analytes including low abundant proteins and peptides in times as short as 30 minutes.


US Patent No. 8,685,711. Methods and compositions for highly sensitive detection of molecules. Inventors: Philippe Goix; Robert Puskas; John Todd; Richard Livingston; Douglas Held. Assignee: Singulex

Covers kits and methods for highly sensitive detection of molecules.


US Patent No. 8,685,659. Method for diagnosis and prognosis of epithelial cancers. Inventors: Bruce Zetter; Adam Feldman; Scott McDougal. Assignees: Children's Medical Center Corporation; The General Hospital Corporation

Covers a method of diagnosing and prognosing bladder cancer based on measurements of the proteins cystatin B, chaperonin 10, and profiling.


US Patent No. 8,685,218. Precision flow control system. Inventors: Phillip Paul; Jason Rehm; Don Arnold. Assignee: AB Sciex

Covers a precision flow controller that provides a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flow rate is less than five percent of the flow rate.


US Patent No. 8,679,773. Kits pertaining to analyte determination. Inventors: Darryl Pappin; Michael Bartlett-Jones. Assignee: DH Technologies Development

Covers methods of identifying analytes by mass analysis using isomeric or isobaric labeling reagents.


US Patent No. 8,679,772. Immunoassay. Inventors: Zhiqiang Gao; Jie Zhang. Assignee: Agency for Science, Technology and Research

Covers an immunoassay in which an antibody on an electrode is exposed to an analyte-containing liquid to bind the analyte to the antibody. Detection of this binding is accomplished by measurement of the magnetic current between this electrode and a reference electrode.


US Patent No. 8,679,771. Specific N-terminal labeling of peptides and proteins in complex mixtures. Inventors: James Wells; Sami Mahrus. Assignee: University of California

Covers methods for selectively labeling the N-termini of proteins with synthetic peptides.


US Patent No. 8,679,769. Detection of endometrial secretion markers for assessment of endometriosis. Inventors: Daniel Nagore; Amagoia Ametzazurra; Antonio Martinez; Laureano Buela. Assignee: Proteomike

Covers biomarkers for diagnosis or prognosis of endometriosis.


US Patent No. 8,669,117. Method for single oxygen atom incorporation into peptides. Inventors: Masaru Miyagi; Chandra sekhar rao Kadiyala. Assignee: University of North Dakota

Covers methods of incorporating an oxygen atop into digested peptides for labeling of samples for quantification.


US Patent No. 8,669,067. Cancer biomarker and the use thereof. Inventor: Yoon Lim. Assignee: National University of Singapore

Covers the use of complement component C9 protein as a biomarker for identifying gastric cancer.


US Patent No. 8,668,978. Multi-biomarker biosensor. Inventors: Asanterabi Malima; Ahmed Busnaina; Salome Siavoshi; Sivasubramanian Somu; Cihan Yilmaz; Tiziana Musacchio; Jaydev Upponi; Vladimir Torchilin. Assignee: Northeastern University

Covers methods of using nanaosubstrates as biosensors.


US Patent No. 8,664,358. Predictive markers for ovarian cancer. Inventors: Brian Mansfield; Ping Yip; Suraj Amonkar; Greg Bertenshaw. Assignee: Vermillion

Covers biomarkers for predicting the presence, subtype and stage of ovarian cancer, as well as for assessing the therapeutic efficacy of a cancer treatment and determining whether a subject potentially is developing cancer.


US Patent No. 8,663,959. Preparing biological samples for analysis. Inventors: Karl Skold; Marcus Svensson; Goran Palmers; Per Erik Andren. Assignee: Denator.

Covers methods for preparing biological samples by rapidly and uniformly heating it to preserve its primary structure.


US Patent No. 8,658,572. Whole proteome tiling microarrays. Inventors: Tom Albert; Todd Richmond; Matthew Rodesch; Klaus-Peter Stengele; Jochen Buhler. Assignee: Roche Nimblegen

Covers a microarray comprising at least 50,000 oligopeptide features per cm and representing 50 percent or more of the proteome of an organism.


US Patent No. 8,658,355. General mass spectrometry assay using continuously eluting co-fractionating reporters of mass spectrometry detection efficiency. Inventor: Michael Heaven. Assignee: UAB Research Foundation

Covers a method for quantifying analytes via mass spec using reporters such as synthetic peptides for standardization.


US Patent No. 8,658,133. Methods and compositions relating to Alzheimer's disease. Inventors: Malcolm Ward; Vaksha Patel; Emma McGregor; Nicola Leeds; Helen Byers; James Campbell; Kit-Yi Leung; Jules Westbrook. Assignee: Proteome Sciences

Covers proteins differentially expressed in Alzheimer's disease versus controls as well as methods for identification of these and other proteins as potential drug targets and measures of therapeutic efficacy.


US Patent No. 8,647,880. Mass spectrometry-based protein identification method with selective N-terminus derivatization. Inventors: Mario Cindric; Sandra Pavelic; Anita Horvatic; Ivana Dodig. Assignee: Rudjer Bosckovic Institute

Covers a method for detection of amino acid sequences and identification of proteins and peptides based on derivatization of peptides or proteins using compounds comprising two or more sulfonyl groups, and subsequent analysis of the derivatized analytes using mass spec.

The Scan

Booster Push

New data shows a decline in SARS-CoV-2 vaccine efficacy over time, which the New York Times says Pfizer is using to argue its case for a booster, even as the lower efficacy remains high.

With Help from Mr. Fluffington, PurrhD

Cats could make good study animals for genetic research, the University of Missouri's Leslie Lyons tells the Atlantic.

Man Charged With Threatening to Harm Fauci, Collins

The Hill reports that Thomas Patrick Connally, Jr., was charged with making threats against federal officials.

Nature Papers Present Approach to Find Natural Products, Method to ID Cancer Driver Mutations, More

In Nature this week: combination of cryogenic electron microscopy with genome mining helps uncover natural products, driver mutations in cancer, and more.