Skip to main content
Premium Trial:

Request an Annual Quote

Intrinsic Bioprobes Receives US Patent for Protein Biomarkers for Myocardial Infarction

Premium

Biomarker discovery firm Intrinsic Bioprobes announced this week that it has been granted a US patent for biomarkers and assays for the determination of myocardial infarction.

According to the patent, US No. 7,816,095, the company identified the proteins serum amyloid A and S-sulfonated transthyretin as biomarkers for myocardial infarction and developed a three-marker panel consisting of SAA, SS-TTR, and known MI biomarker myoglobin that in a 192-sample study demonstrated predictive power exceeding that of conventional MI assays.

In addition to being useful for detecting myocardial infarction, the biomarkers are also interesting in that "they clearly demonstrate the significance of protein microheterogeneity in human disease, which has been a largely unexplored niche in human molecular biology," Urban Kiernan, the company's director of biomarker discover, said in a statement.

The biomarkers were discovered using Intrinsic Bioprobe's mass spectrometric immunoassay technology – a patented pipette immunoenrichment method that uses a high-throughput, high-binding-capacity microcolumn activated with antibodies to isolate low-abundance proteins in complex samples. Researchers analyze the isolated proteins via single reaction-monitoring mass spec, which enables them to quantitate protein variants.

In July, the company announced an agreement with Thermo Fisher Scientific to co-develop and market protein biomarker assays based on the technology (PM 07/15/2010).

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.