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Hybrigenics, Structural Bioinformatics, J&J, Applied Biosystems


Hybrigenics Raises Additional $14.8M


Hybrigenics said last week that it has raised 16.8 million, or roughly $14.8 million, in a Series C round of venture capital financing.

The financing, which brings Hybrigenics’ total take to 47 million since its founding in December 1997, will be used to bolster its therapeutic-target validation, emphasizing infectious-diseases drug discovery. The funds will also help support Hybrigenics’ internal and external growth, and to reinforce its international business presence, the company said.

Life Sciences Partners, based in the Netherlands and Germany, led the round.


J&J Expands Protein Structure Determination Contract With SBI


Structural Bioinformatics said last week that it has expanded the scale of its protein crystallization work for Johnson & Johnson Pharmaceutical Research and Development. San Diego-based SBI first began determining the structures of crystallized proteins and drug-protein complexes for J&J in January 2001. David Muth, SBI’s president, declined to disclose the number of new proteins SBI would study for J&J, but said the new collaboration would expand the number of targets and extend the timeframe of the contract research. SBI has access to MAR Research x-ray crystallography equipment at the University of California, San Diego, x-ray crystallography facility.


ABI Expects to Sell 50 TOF/TOFs in 2002; Sales Could be Worth $38M


Applied Biosystems expects to sell around 50 of its 4700 Proteomics Analyzer MALDI TOF/TOF machines during 2002, according to Banc of America analyst James Reddoch. The potential sales would represent around 4 percent of ABI’s total, or $38 million. In a report, Reddoch said ABI may post strong sales of MALDI-TOF/TOFs even “in a tough environment,” but that “we would be cautious buying ABI [stock] before the company reports its [revenues for the third quarter of fiscal 2002].”

The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.