Skip to main content
Premium Trial:

Request an Annual Quote

Gentel and Van Andel Receive Patent for GlycoProtein Profiling Technology

Premium

Proteomics firm Gentel Biosciences and Van Andel Research Institute said this week that they've been granted a US patent covering a technique for profiling changes in the glycosylation of proteins captured on an antibody array slide.

The patent, number 7,838,634, covers a "high-throughput method of screening for a biomarker indicative of a disease" and includes "methods utilizing a microarray to measure the glycan level of a protein."

Comprising roughly 80 percent of the protein biomarkers currently in clinical use, glycoproteins are a significant area of focus for biomarker research, and, VARI researcher Brian Haab said in a statement, "the ability to efficiently screen glycosylated variants of many proteins for use as biomarkers offers an unprecedented opportunity for discoveries of new glycan-based biomarkers."

Gentel owns exclusive rights to the technology through a licensing agreement it signed with VARI in 2006. It now plans to combine the glycan detection technology with more than 50 of its SilverQuant Antibody Array kits, which use chromogenic reagents for the detection of target proteins.

A patent for the technology is also pending in the European Union.

The Scan

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.

Sequencing Study Leads to Vaccine Target in Bacteria Behind Neonatal Meningitis

Researchers eBioMedicine track down potential vaccine targets with transposon sequencing on mutant bacteria causing neonatal meningitis in mouse models of the disease.

Multiple Myeloma Progression Influenced by Immune Microenvironment Expression

Researchers in NPJ Genomic Medicine compare RNA sequencing profiles of 102,207 individual cells in bone marrow samples from 18 individuals with rapid or non-progressing multiple myeloma.

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.