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Funding Update: NSF Grants Awarded to UW-Madison, University of Michigan


Recent NSF Awards in Proteomics and Protein Research

Title: Amyloid Regulatory Networks
Principal Investigator: Regina Murphy
Sponsor: University of Wisconsin-Madison
Start/End Date: June 1, 2013 – May 31, 2016
Amount Awarded to Date: $390,001

Funds an effort to investigate the non-self association between amyloidogenic proteins, examining roughly 100 different pairs of proteins to determine if they interact. For interacting proteins, experiments will be done to identify the portions of the proteins involved in the interaction and to measure the effect of these interactions on progression on the amyloidogenesis pathway.

Title: Next-Generation Ion Mobility-Mass-Spectrometry of Protein-ligand and Multiprotein Complexes
Principal Investigator: Brandon Ruotolo
Sponsor: University of Michigan Ann Arbor
Start/End Date: May 1, 2013 – April 30, 2018
Amount Awarded to Date: $250,000

Funds development of a mass spec technique combining nanospray ionization with ion-mobility mass spec to investigate drug molecule binding with multi-protein complexes.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.