Recent NSF Awards in Proteomics and Protein Research
Title: Acquisition of an Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) LC/MS for Multidisciplinary Research, Research Training, and Education at Tuskegee University
Principal Investigator: Marilyn Tourne
Sponsor: Tuskegee University
Start/End Date: Aug. 31, 2014 – July 31, 2017
Amount Awarded to Date: $420,800
Funds the acquisition of a QTOF mass spectrometer for research into areas including protein-protein interactions, use of metal nanoparticles for production of ethanolic biofules, and identifying small molecules and their binding to targets.
Title: Ultraviolet Photodissociation Mass Spectrometry
Principal Investigator: Jennifer Brodbelt
Sponsor: University of Texas at Austin
Start/End Date: Sept. 1, 2014 – Aug. 31, 2017
Amount Awarded to Date: $495,000
Funds work on developing UV photodissociation as a strategy for the analysis of proteins by mass spec and particularly for the analysis of intact proteins.
Title: Lab-in-a-Smartphone
Principal Investigators: Brian Cunningham, John Dallesasse
Sponsor: University of Illinois at Urbana-Champaign
Start/End Date: Sept. 1, 2014 – Aug. 31, 2016
Amount Awarded to Date: $300,000
Funds development of a smartphone-based system for performing analyses including UV/Visible wavelength absorption spectroscopy, UV/Visible wavelength reflectance spectroscopy, Raman spectroscopy, surface-enhanced Raman spectroscopy, and label-free optical biosensor measurements.
Title: Analysis of Bovine Epididymal and Chicken SST Sperm to Determine Proteins Involved in Sperm Preservation
Principal Investigator: George Perry
Sponsor: South Dakota State University
Start/End Date: Sept. 1, 2014 – Aug. 31, 2016
Amount Awarded to Date: $299,977
Funds mass spec-based research comparing the proteomes of bovine epididymal sperm and ejaculated sperm to that of chicken sperm stored in the female reproductive tract to investigate mechanisms by which sperm can be stored in the female reproductive tract of chickens and epididymis of the bull to allow artificial insemination of farm animals.
Title: The Molecular Interactome of Synaptogenesis
Principal Investigators: Gaetano Montelione, Davide Comoletti
Sponsor: Rutgers University
Start/End Date: Sept. 1, 2014 – Aug. 31, 2014
Amount Awarded to Date: $300,000
Funds development of a high-throughput approach to build an experimentally validated protein interaction network covering synaptic proteins and exodomains.
Title: Acquisition of a High Resolution Orbitrap Liquid Chromatograph Tandem Mass Spectrometer for Enhancing Research and Education
Principal Investigators: Stephen Bergmeier, Hao Chen, Justin Holub, Michael Held, Marcia Kieliszewski
Sponsor: Ohio University
Start/End Date: Aug. 1, 2014 – July 31, 2017
Amount Awarded to Date: $398,414
Funds acquisition of an Orbitrap mass spectrometer for research including glycoprotein characterization, investigating protein redox chemistry, and developing chemometric approaches for the identification of biomarkers.
Title: Leucine Aminopeptidase – Regulator of the Stress-Induced Stromal Proteome
Principal Investigator: Linda Walling
Sponsor: University of California-Riverside
Start/End Date: Aug. 1, 2014 – July 31, 2015
Amount Awarded to Date: $126,142
Funds research into the role of leucine aminopeptidase (LAP-A) in signaling that controls nuclear gene expression after insect feeding and wounding. The work will use proteomics to compare protein levels in different tomato lines expressing different amounts of LAP-A.
Title: Acquisition of a Liquid Chromatography/Mass Spectrometer for Accurate Mass Determination and Complex Mixture Analysis
Principal Investigators: Patrick Willoughby, Colleen Byron, Robert Wallace
Sponsor: Ripon College
Start/End Date: Aug. 1, 2014 – July 31, 2017
Amount Awarded to Date: $237,383
Funds acquisition of a QTOF mass spectrometer for study in areas including investigating the effects of byproducts of reactive oxygen species on electron-transferring proteins.