Recent NSF Awards in Proteomics and Protein Research
Title: Predicting and Mining Phenome-Genome Association across Species
Principal Investigator: Rui Kuang
Sponsor: University of Minnesota-Twin Cities
Start/End Date: Aug. 1, 2012 – July 31, 2017
Amount Awarded to Date: $83,847
Funds the development of algorithms to predict and interpret associations between genotype and phenotype across a variety of species. Once developed, the methods will be applied to the study of growth phenotypes in Arabidopsis thaliana and in the analysis of phenotypes in several tumor types.
Title: Precise Characterization of Conformational Ensembles
Principal Investigators: Lee Makowski; Dana Brooks; Deniz Erdogmu
Sponsor: Northeastern University
Start/End Date: July 1, 2012 – June 30, 2015
Amount Awarded to Date: $657,070
Funds an effort to characterize the set of all shapes particular proteins can take – their full conformational ensemble – by collecting wide-angle x-ray solution scattering data from the target proteins under a variety of different conditions. This will enable the creation of a map of protein conformational changes that can be used to further functional studies.