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Funding Update: NSF Grants Awarded to University of Michigan; Arizona State; and More


Recent NSF Awards in Proteomics and Protein Research

Title: Development of Microsecond Time-Resolved Mass Spectrometry for the Study of Biochemical Reaction Mechanisms and Kinetics
Principal Investigator: Hao Chen
Sponsor: Ohio University
Start/End Date: April 1, 2012 — March 31, 2017
Amount Awarded to Date: $111,044

Funds the development of microsecond time-resolved mass spectrometry based on ionization of a flying liquid jet created by ultrafast mixing of reactant solutions by an ambient ionization method with the aim of improving sampling resolution from the current millisecond range to microsecond time resolution.

Title: Fundamental and Mechanistic Studies of Negative Ion Electron Capture Dissociation
Principal Investigator: Kristina Hakansson
Sponsor: University of Michigan Ann Arbor
Start/End Date: April 1, 2012 – March 31, 2015
Amount Awarded to Date: $400,000

Funds an effort to investigate and improve the usefulness of negative ion electron capture dissociation tandem mass spec, with the aim of developing new methods for characterizing a variety of molecules including intact acidic proteins and phosphor- and sulfopeptides.

Title: Virtual, High-throughput Model of Brain Microvasculature Regeneration
Principal Investigator: Amina Qutub
Sponsor: William Marsh Rice University
Start/End Date: March 1, 2012 – Feb. 28, 2017
Amount Awarded to Date: $435,097

Funds work to develop a model of brain microvasculature formation in hypoxia by linking cell behavior patterns to intracellular protein signaling. The grantees plan to map behavior to protein expression through an integrated experimental-computational approach using high-throughput arrays.

Title: Functional Characterization of a Multi-Enzyme Complex Involved in Xylan Synthesis in Wheat
Principal Investigator: Ahmed Faik
Sponsor: Ohio University
Start/End Date: March 1, 2012 – Feb. 28, 2015
Amount Awarded to Date: $140,000

Supports a project combining proteomics with a variety of other methods to identify and determine the function of proteins that are part of the xylan synthase complex in wheat and then investigate the assembly of these proteins into a functional complex.

Title: Novel Voltage-gated Solid State Nanopore Technologies Resembling Natural Ion Channel Proteins
Principal Investigator: Michael Goryll
Sponsor: Arizona State University
Start/End Date: March 1, 2012 – Feb. 28, 2017
Amount Awarded to Date: $400,000

Funds work on recreating the functionality of a natural ion channel using a solid-state nanopore in order to create biosensors capable of operating in a wide range of environmental conditions.

Title: Systems Analysis of Protein Interactome in Cytosol and Nuclei of Developing Soybean and Rapeseed Embryos
Principal Investigator: Jay Thelen
Sponsor: University of Missouri-Columbia
Start/End Date: Feb. 15, 2012 – Jan. 31, 2014
Amount Awarded to Date: $500,000

Covers an effort to systematically and quantitatively analyze protein-protein interactions in cytosolic and nuclear fractions of developing soybean and rapeseed embryos, as well as perform bioinformatic analyses of potential interacting proteins based on this data.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.