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Funding Update: NSF Grants Awarded to Tufts, University of Minnesota, and More


Recent NSF Awards in Proteomics and Protein Research

Title: Acquisition of a Quadrupole Time-of-Flight Mass Spectrometer for Proteomics and Metabolomics
Principal Investigators: Kyongbum Lee, David Kaplan, Qiaobing Xu, Lauren Black
Sponsor: Tufts University
Start/End Date: Oct. 1, 2013 – Sept. 30, 2016
Amount Awarded to Date: $388,652

Funds the acquisition of a Q-TOF mass spec for use in analyzing proteins and peptides as well as metabolites and other small molecules.

Title: Scalable Nanomanufacturing of Cyclic Peptide-Based Nanorobots for In Vivo Sensing
Principal Investigator: Mingjun Zhang
Sponsor: University of Tennessee, Knoxville
Start/End Date: Sept. 1, 2013 – Aug. 31, 2016
Amount Awarded to Date: $288,948

Funds development of a nanomanufacturing platform for fabricating cyclic peptide-based nanorobots linked to DNA aptamers that can release a target payload in response to binding of a target biomarker to the linked aptamer. These devices can be used for a variety of applications including in vivo sensing and targeted drug delivery.

Title: Acquisition of a MALDI-TOF/TOF Mass Spectrometer for Molecular Structure Determination and Imaging
Principal Investigators:Michael Bowser, Joseph Dalluge
Sponsor: University of Minnesota-Twin Cities
Start/End Date: Sept. 1, 2013 – Aug. 31, 2016
Amount Awarded to Date: $285,544

Funds acquisition of a MALDI-TOF/TOF mass spec for applications including characterizing engineered tissues, studying the localization of autophagy markers, and characterizating bioactive proteins and nucleic acids.

Title: Quantitative Biosensing at the Single-molecule Level
Principal Investigator: Joel Harris
Sponsor: University of Utah
Start/End Date: Sept. 1, 2013 – Aug. 31, 2016
Amount Awarded to Date: $400,000

Funds work on developing new microscopy methods to optimize sensors for ultrasensitive detection of biomolecules by quantitative single-molecule imaging.

Title: Optogenetic Dissection of Protein Kinase Networks
Principal Investigators: Alexander Deiters, Jason Haugh
Sponsor: University of Pittsburgh
Start/End Date: Sept. 1, 2013 – Aug. 31, 2016
Amount Awarded to Date: $625,000

Funds research into a method of controlling kinases via light by genetically encoding them to contain a caged lysine residue that allows researchers to activate the enzyme upon exposure to UV light. These reagents will be used to elucidate patterns of kinase signaling.

Title: Profiling Dynamic Changes in Animal Circadian Clock Protein Networks
Principal Investigator:Joanna Chiu
Sponsor: University of California-Davis
Start/End Date: Aug. 1, 2013 – July 31, 2014
Amount Awarded to Date: $149,995

Funds an effort to study the dynamic interactions between circadian oscillator protein complexes and other cellular machinery using mass spec-based proteomics.

The Scan

Genetic Ancestry of South America's Indigenous Mapuche Traced

Researchers in Current Biology analyzed genome-wide data from more than five dozen Mapuche individuals to better understand their genetic history.

Study Finds Variants Linked to Diverticular Disease, Presents Polygenic Score

A new study in Cell Genomics reports on more than 150 genetic variants associated with risk of diverticular disease.

Mild, Severe Psoriasis Marked by Different Molecular Features, Spatial Transcriptomic Analysis Finds

A spatial transcriptomics paper in Science Immunology finds differences in cell and signaling pathway activity between mild and severe psoriasis.

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.