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Funding Update: NSF Grants Awarded to Tufts, University of Minnesota, and More


Recent NSF Awards in Proteomics and Protein Research

Title: Acquisition of a Quadrupole Time-of-Flight Mass Spectrometer for Proteomics and Metabolomics
Principal Investigators: Kyongbum Lee, David Kaplan, Qiaobing Xu, Lauren Black
Sponsor: Tufts University
Start/End Date: Oct. 1, 2013 – Sept. 30, 2016
Amount Awarded to Date: $388,652

Funds the acquisition of a Q-TOF mass spec for use in analyzing proteins and peptides as well as metabolites and other small molecules.

Title: Scalable Nanomanufacturing of Cyclic Peptide-Based Nanorobots for In Vivo Sensing
Principal Investigator: Mingjun Zhang
Sponsor: University of Tennessee, Knoxville
Start/End Date: Sept. 1, 2013 – Aug. 31, 2016
Amount Awarded to Date: $288,948

Funds development of a nanomanufacturing platform for fabricating cyclic peptide-based nanorobots linked to DNA aptamers that can release a target payload in response to binding of a target biomarker to the linked aptamer. These devices can be used for a variety of applications including in vivo sensing and targeted drug delivery.

Title: Acquisition of a MALDI-TOF/TOF Mass Spectrometer for Molecular Structure Determination and Imaging
Principal Investigators:Michael Bowser, Joseph Dalluge
Sponsor: University of Minnesota-Twin Cities
Start/End Date: Sept. 1, 2013 – Aug. 31, 2016
Amount Awarded to Date: $285,544

Funds acquisition of a MALDI-TOF/TOF mass spec for applications including characterizing engineered tissues, studying the localization of autophagy markers, and characterizating bioactive proteins and nucleic acids.

Title: Quantitative Biosensing at the Single-molecule Level
Principal Investigator: Joel Harris
Sponsor: University of Utah
Start/End Date: Sept. 1, 2013 – Aug. 31, 2016
Amount Awarded to Date: $400,000

Funds work on developing new microscopy methods to optimize sensors for ultrasensitive detection of biomolecules by quantitative single-molecule imaging.

Title: Optogenetic Dissection of Protein Kinase Networks
Principal Investigators: Alexander Deiters, Jason Haugh
Sponsor: University of Pittsburgh
Start/End Date: Sept. 1, 2013 – Aug. 31, 2016
Amount Awarded to Date: $625,000

Funds research into a method of controlling kinases via light by genetically encoding them to contain a caged lysine residue that allows researchers to activate the enzyme upon exposure to UV light. These reagents will be used to elucidate patterns of kinase signaling.

Title: Profiling Dynamic Changes in Animal Circadian Clock Protein Networks
Principal Investigator:Joanna Chiu
Sponsor: University of California-Davis
Start/End Date: Aug. 1, 2013 – July 31, 2014
Amount Awarded to Date: $149,995

Funds an effort to study the dynamic interactions between circadian oscillator protein complexes and other cellular machinery using mass spec-based proteomics.

The Scan

Could Cost Billions

NBC News reports that the new Alzheimer's disease drug from Biogen could cost Medicare in the US billions of dollars.

Not Quite Sent

The Biden Administration likely won't meet its goal of sending 80 million SARS-CoV-2 vaccine doses abroad by the end of the month, according to the Washington Post.

DTC Regulation Proposals

A new report calls on UK policymakers to review direct-to-consumer genetic testing regulations, the Independent reports.

PNAS Papers on Mosquito MicroRNAs, Acute Kidney Injury, Trichothiodystrophy

In PNAS this week: microRNAs involved in Aedes aegypti reproduction, proximal tubule cell response to kidney injury, and more.