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Funding Update: NSF Grants Awarded to Purdue; UW-Madison; and More

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Recent NSF Awards in Proteomics and Protein Research

Title: Development of a Conformational Screen for Rapidly Identifying Kinase Inhibitor Type Using SHG
Principal Investigator: Joshua Salafsky
Sponsor: Biodesy
Start/End Date: Jan. 1, 2012 – June 30, 2012
Amount Awarded to Date: $150,000

Funds development of an optical platform to measure protein conformation in order to identify ligands that bind to target proteins. The project aims to investigate the conformation changes of Abl kinase in the presence of various classes of inhibitors with the larger goal of developing a screening platform for therapeutics.


Title: Functionalized Graphene-Based Biosensors
Principal Investigator: Christian Punckt
Sponsor: Vorbeck Materials
Start/End Date: Jan. 1, 2012 – June 30, 2012
Amount Awarded to Date: $149,892

Funds work on developing materials based on functionalized graphene sheets for the building of electrochemical biosensors for a range of analytes including proteins.


Title: High-Throughput Multi-Analyte ChIP Assay Development
Principal Investigators: MaryAnne Jelinek
Sponsor: Active Motif
Start/End Date: Jan. 1, 2012 – June 30, 2012
Amount Awarded to Date: $150,000

Funds development of a high-throughput, multi-analyte chromatin immunoprecipitation system that will allow the barcoding of antibodies by inclusion of unique DNA sequences allowing for readout via next-generation sequencing.


Title: Novel Quantitative Proteomic Methods to Discover and Localize Endogenous Protein Complexes
Principal Investigators: Daniel Szymanski, Jun Xie, Daisuke Kihara, Mark Hall
Sponsor:Purdue University
Start/End Date: Dec. 15, 2011 – Nov. 30, 2013
Amount Awarded to Date: $604,999

Funds an investigation of endogenous protein complexes in crop plants using quantitative label-free mass spectrometry to identify co-purifying groups of proteins that reveal protein complexes. The researchers aim to predict and validate the composition of 100 complexes from lead cytosol.


Title: Symposium on Comparative Proteomics of Environmental and Pollution Stress Jan. 3-7, 2012 Charleston South Carolina.
Principal Investigator: Lars Tomanek
Sponsor: California Polytechnic State University Foundation
Start/End Date: Dec. 15, 2011 – Nov. 30, 2012
Amount Awarded to Date: $14,990

Funds a symposium focusing on the changes in the proteome of organisms in response to environmental stressors. The symposium will feature proteomic analyses currently being done on non-model or marine model organisms and bring together scientists in the field to share their latest research results.


Title: Molecular Analysis of Proteins Involved in Plant Endocytosis and Cytokinesis
Principal Investigators: Sebastian Bednarek, Kevin Eliceiri
Sponsor: University of Wisconsin-Madison
Start/End Date: Dec. 1, 2011 – Nov. 30, 2014
Amount Awarded to Date: $249,999

Funds research into plant endocytic machinery including proteomic, genetic, biochemical, and imaging studies to identify and characterize proteins involved in the formation and targeting of plant clathrin-coated endocytic vesicles.

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.