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Funding Update: NSF Grants Awarded to Penn State, UMass, and More


Recent NSF Awards in Proteomics and Protein Research

Title: Multidimensional Mass Spectrometry Methods for the Study of Polymer Structures, Architectures, and Interactions
Principal Investigator: Chrys Wesdemiotis
Sponsor: University of Akron
Start/End Date: Jan 1, 2014 – Dec. 31, 2016
Amount Awarded to Date: $440,000

Funds research into mass spectrometric methods for characterizing the microstructures of synthetic polymers including measuring changes in proteins that interact with the polymers and quantifying protein adhesion to them.

Title: Plasmon-Enhanced Chiroptical Biosensors
Principal Investigator: Vincent Rotello
Sponsor: University of Massachusetts, Amherst
Start/End Date: Aug. 1, 2013 – July 31, 2016
Amount Awarded to Date: $400,000

Covers an effort to build new biosensors based on plasmon-enhanced chiroptical sensing capable of detecting minute changes in serum protein levels. The researchers will apply the high sensitivity and structural information provided by plasmon-enhanced chiroptical sensing to array-based sensing, using synthetic systems, self-assembly, and nanopatterning to create more efficient sensor systems.

Title: Lab-on-CMOS Electrochemical Microsystem for High-Throughput Characterization of Membrane Proteins
Principal Investigators: Andrew Mason, R. Garavito
Sponsor: Michigan State University
Start/End Date: Aug. 1, 2013 – July 31, 2015
Amount Awarded to Date: $360,000

Funds the development of a lab-on-CMOS device that integrates a 1,000-element array of microfluidic planar-BLM chambers with embedded CMOS electrochemical instrumentation circuits, allowing for high-throughput characterization of membrane proteins.

Title: Dynamic Affinity for Regulation of Cell Signaling
Principal Investigator: Cheng Dong
Sponsor: Pennsylvania State University
Start/End Date: July 15, 2013 – June 30, 2015
Amount Awarded to Date: $200,000

Funds studies to determine how the dynamic affinities between cell receptors and their ligands affect intracellular signaling.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.