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Funding Update: NSF Grants Awarded to Old Dominion, Rensselaer Polytechnic, and More


Recent NSF Awards in Proteomics and Protein Research

Title: Development of Ultrasensitive, Superfast, and Microliter-Volume Differential Scanning Nanocalorimeter for Direct Characterization of Biomolecular Interactions
Principal Investigator: Lei Zuo
Sponsor: SUNY at Stony Brook
Start/End Date: Jan. 15, 2013 – Dec. 31, 2015
Amount Awarded to Date: $300,000

Funds the development of a MEMS-based differential scanning nanocalorimeter and array to enable measurement of molecular interactions including protein-ligand binding with smaller amounts of sample and in shorter time than possible with current technology.

Title: Topology-based Approaches to Integrated Analysis of Transcriptomic, Protein Interactomic and Phenotypic data
Principal Investigator: Jianhua Ruan
Sponsor: University of Texas at San Antonio
Start/End Date: Oct. 1, 2012 – Sept. 30, 2015
Amount Awarded to Date: $150,000

Funds the development of algorithms and software to improve network and network module discovery using network topology information, to investigate links between network topology and biological function, and to identify potential causal genes associated with cancer phenotypes.

Title: Linking Geochemistry and Proteomics to Reveal the Impact of Bacteria on Protein Cycling in the Ocean
Start/End Date: Oct. 1, 2012 – Sept. 30, 2015
Sponsor: H. Rodger Harvey
Start/End Date: Old Dominion University Research Foundation
Amount Awarded to Date: $349,000

Funds work using mass spec-based proteomics to identify bacterial proteins synthesized during organic matter recycling with the aim of determining the contribution of bacteria proteins to marine organic matter and determining if glycan modifications are a key component of peptides seen in past analyses of oceanic particles and sediment.

Title: Multimodal Membranes for High-throughput Bioseparations
Principal Investigator: Scott Husson
Sponsor: Clemson University
Start/End Date: Sept. 15, 2012 – Aug. 31, 2015
Amount Awarded to Date: $262,086

Funds a project using multimodal ligands to develop advanced membrane adsorbers to allow higher volume chromatographic separations.

Title: Molecular Engineering of Multiple Weak Interactions for High Selectivity Bioseparations
Principal Investigator: Steven Cramer; Shekhar Garde; Scott McCallum
Sponsor: Rensselaer Polytechnic Institute
Start/End Date: Sept. 15, 2012 – Aug. 31, 2015
Amount Awarded to Date: $340,000

Covers research into multimodal ligand-protein interactions in the presence of FPMs to develop improved understanding of the nature of MM ligand binding to proteins in the presence of FPMs for the purpose of developing improved MM chromatographic systems.

Title: Design of Conformation-Specific Antibodies Against Unfolded and Misfolded Proteins
Principal Investigator: Peter Tessier
Sponsor: Rensselaer Polytechnic Institute
Start/End Date: Sept. 1, 2012 – Aug 31, 2015
Amount Awarded to Date: $300,000

Funds research into methods of developing antibodies to unfolded and misfolded proteins.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.