Recent NSF Awards in Proteomics and Protein Research
Title: Scalable Nanomanufacturing of Cyclic Peptide-Based Nanorobots for In Vivo Sensing
Principal Investigator: Mingjun Zhang
Sponsor: Ohio State University
Start/End Date: Jan. 1, 2014 – Aug. 31, 2016
Amount Awarded to Date: $288,948
Funds the development of a nanomanufacturing platform for fabricating cyclic peptide-based nanorobots for biomedical applications. The robots will consist of peptide-based nanotubes connected with DNA-based aptamers that will serve as biosensors for purposes including biomarker detection and targeted drug discovery.
Title: Global Analysis of In Vivo Protein Folding Efficiencies by Mass Spectrometry
Principal Investigator: Sina Ghaemmaghami
Sponsor: University of Rochester
Start/End Date: Jan. 1, 2014 – Dec. 31, 2018
Amount Awarded to Date: $190,000
Funds development of mass spec techniques for quantifying the proportion of proteins that successfullly fold in a cell after protein synthesis with the larger aim of studying folding efficiencies of different proteins and identifying relationships between the physical properties of a protein and their propensity to fold properly.