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Funding Update: NSF Grants Awarded to Ohio State, University of Rochester

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Recent NSF Awards in Proteomics and Protein Research

Title: Scalable Nanomanufacturing of Cyclic Peptide-Based Nanorobots for In Vivo Sensing
Principal Investigator: Mingjun Zhang
Sponsor: Ohio State University
Start/End Date: Jan. 1, 2014 – Aug. 31, 2016
Amount Awarded to Date: $288,948

Funds the development of a nanomanufacturing platform for fabricating cyclic peptide-based nanorobots for biomedical applications. The robots will consist of peptide-based nanotubes connected with DNA-based aptamers that will serve as biosensors for purposes including biomarker detection and targeted drug discovery.


Title: Global Analysis of In Vivo Protein Folding Efficiencies by Mass Spectrometry
Principal Investigator: Sina Ghaemmaghami
Sponsor: University of Rochester
Start/End Date: Jan. 1, 2014 – Dec. 31, 2018
Amount Awarded to Date: $190,000

Funds development of mass spec techniques for quantifying the proportion of proteins that successfullly fold in a cell after protein synthesis with the larger aim of studying folding efficiencies of different proteins and identifying relationships between the physical properties of a protein and their propensity to fold properly.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.