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Funding Update: NSF Grants Awarded to Ohio State, University of Rochester


Recent NSF Awards in Proteomics and Protein Research

Title: Scalable Nanomanufacturing of Cyclic Peptide-Based Nanorobots for In Vivo Sensing
Principal Investigator: Mingjun Zhang
Sponsor: Ohio State University
Start/End Date: Jan. 1, 2014 – Aug. 31, 2016
Amount Awarded to Date: $288,948

Funds the development of a nanomanufacturing platform for fabricating cyclic peptide-based nanorobots for biomedical applications. The robots will consist of peptide-based nanotubes connected with DNA-based aptamers that will serve as biosensors for purposes including biomarker detection and targeted drug discovery.

Title: Global Analysis of In Vivo Protein Folding Efficiencies by Mass Spectrometry
Principal Investigator: Sina Ghaemmaghami
Sponsor: University of Rochester
Start/End Date: Jan. 1, 2014 – Dec. 31, 2018
Amount Awarded to Date: $190,000

Funds development of mass spec techniques for quantifying the proportion of proteins that successfullly fold in a cell after protein synthesis with the larger aim of studying folding efficiencies of different proteins and identifying relationships between the physical properties of a protein and their propensity to fold properly.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.