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Funding Update: NSF Grants Awarded to CUNY Queens College, Fyodor Biotechnologies, and More

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Recent NSF Awards in Proteomics and Protein Research

Title: Nanopipette-Based Immunosensor
Principal Investigator: Michael Mirkin
Sponsor: CUNY Queens College
Start/End Date: Dec. 1, 2012 – May 31, 2014
Amount Awarded to Date: $100,000

Funds the development of a biosensor platform for detection of antibodies and protein biomarkers using nanometer-sized pipettes to sense analytes based on changes in ion current flowing through the aperture upon target capture.


Title: Workshop on Comparative Proteomics of Environmental and Pollution Stress
Principal Investigator: Lars Tomanek
Sponsor: California Polytechnic State University
Start/End Date: Sept. 15, 2012 – Aug. 31, 2013
Amount Awarded to Date: $35,000

Funds a five-day workshop introducing 12 participants to proteomic techniques including isoelectric and electrophoretic separations and a variety of mass spectrometry methods.


Title: Monitoring and Driving Chemical Response with Single Molecule Nanocircuits
Principal Investigator: Philip Collins
Sponsor: University of California, Irvine
Start/End Date: Sept. 15, 2012 – Aug. 31, 2015
Amount Awarded to Date: $303,683

Funds work on developing molecular electronics for direct reporting of biomolecule activity using a recently developed device architecture that integrates single molecules into functioning carbon nanotube transistor devices, allowing researchers to record chemical events in real time.


Title: Crowding-Assisted Biomolecular Sensing With Natural Nanopores
Principal Investigator: Adrian Parsegian
Sponsor: University of Massachusetts Amherst
Start/End Date: Sept. 1, 2012 – Aug. 31, 2014
Amount Awarded to Date: $209,522

Supports a project exploring the use of polymers and salts for "molecular crowding," driving solutes being analyzed into detector channels to enable single-molecule based detection of molecules including sugars, peptides, and proteins.


Title: Dynamic Self-Assembly of Glycolipids for Unveiling Complex Glycan-Protein Interactions
Principal Investigators: Xiaoyang Zhu; Hung-Wen Liu
Sponsor: University of Texas at Austin
Start/End Date: Aug. 15, 2012 – July 31, 2015
Amount Awarded to Date: $300,000

Funds development of a fluid glycan microarray-based approach to carry out large-scale analysis of glycan binding proteins binding affinity and specificity and for guiding synthesis of oligoglycan structures, with the long-term goal of developing a quantitative tool for analyzing the specificity and selectivity of glycan binding proteins.


Title: Broad-based Urine Test for the Diagnosis of Plasmodium falciparum and P. vivax Malaria in Febrile Patients
Principal Investigator: Edwin Agbo
Sponsor: Fyodor Biotechnologies
Start/End Date: Aug. 15, 2012 – July 31, 2014
Amount Awarded to Date: $476,862

Funds an effort to develop and validate a broad-based, non-invasive, single-step urine-based test for diagnosing malaria via detection of poly-asparagine protein fragments in the urine of malaria patients.


Title: Synergistic Application of Cheminformatics and Computational Geometry Approaches for Predicting Protein-Protein Interactions
Principal Investigators: Alexander Tropsha; Diane Pozefsky; Denis Fourches
Sponsor: University of North Carolina at Chapel Hill
Start/End Date: Aug. 1, 2012 – July 31, 2015
Amount Awarded to Date: $289,892

Funds work on approaches to analyzing protein-protein interactions by developing a new family of cheminformatics descriptors of PPIs derived from Delaunay tessellation of PPI interfaces. The descriptors, called SNAP3 (Simplicial Neighborhood Analysis of Protein-Protein Packing) will be used to develop user-friendly software for analyzing PPIs.


Title: Acquisition of Instrumentation for Spatially Relevant Plant Metabolomics and Proteomics
Principal Investigators: David Gang; Norman Lewis; Sanja Roje; Bernd Lange; David Weller
Sponsor: Washington State University
Start/End Date: Aug. 1, 2012 – July 31, 2015
Amount Awarded to Date: $730,944

Funds the purchase of new mass spectrometry-based imaging systems including a tissue sectioning station and a new MALDI-QTOF mass spectrometer incorporating ion mobility technology.


Title: Acquisition of a High-Sensitivity Triple Quadrupole Mass Spectrometer for the Kansas Lipidomics Research Center
Principal Investigators:Ruth Welti; Kathrin Schrick; Timothy Durrett
Sponsor: Kansas State University
Start/End Date: Aug. 1, 2012 – July 31, 2015
Amount Awarded to Date: $443,484

Funds the purchase of a Waters Xevo TQ-S triple-quadrupole mass spectrometer and ultra-performance liquid chromatography system for mass spec-based lipid analysis.


Title: Statistical Methodology for Network based Integrative Analysis of Omics Data
Start/End Date: Aug. 1, 2012 – July 31, 2016

This award is granted to three investigative teams:

George Michailidis, University of Michigan Ann Arbor, $447,651
Arun Sreekumar, Baylor College of Medicine, $191, 348
Ali Shojaie, University of Washington, $337,069

Covers development of network based methods, algorithms, and software for integration of data across multiple 'omics platforms with the ultimate goal of delineating pathways based on the coordinated activity of genes, transcripts, proteins, and metabolites to identify therapeutic targets and biomarkers for early detection and prognosis of disease.