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Funding Update: NSF Grants Awarded to Columbia, Washington State, and More


Recent NSF Awards in Proteomics and Protein Research

Title: Collision Cross Section Measurements Using Fourier Transform Ion Cyclotron Resonance Techniques
Principal Investigator: David Dearden
Sponsor: Brigham Young University
Start/End Date: July 1, 2014 – June 30, 2017
Amount Awarded to Date: $450,189

Funds research into a technique for detecting and characterizing the shape of large molecules like peptides and proteins on FT-ICR mass specs to allow study of protein assemblies and conformation.

Title: Rapid Gel Microarrays for Low-cost Protein Binding Assays
Principal Investigator: Akwasi Apori
Sponsor: Correlia Biosystems
Start/End Date: July 1, 2014 – Dec. 31, 2014
Amount Awarded to Date: $150,000

Funds development of electrokinetic gel microarray technology that will use functionalized hydrogels within microfluidic systems to pattern and test up to hundreds of analytes.

Title: An Isotope-Assisted Quantitative Phosphoproteomic Analysis of Signaling Pathways Initiated at the Plasma Membrane of Arabidopsis thaliana.
Principal Investigators: Michael Sussman, Sushmita Roy
Sponsor: University of Wisconsin-Madison
Start/End Date: July 1, 2014 – June 30, 2017
Amount Awarded to Date: $457,234

Funds the development of a workflow for phosphoproteomic analysis of Arabidopsis using stable isotope-assisted discovery measurements on a high resolution Orbitrap mass spectrometer followed by targeted measurements using chemically synthesized heavy isotope labeled phosphopeptide standards and a triple quadrupole.

Title: Directed Evolution of Peptides that Bind Protein Targets only in the Presence of Calcium: A New Tool for Bioseparations
Principal Investigator: Scott Banta
Sponsor: Columbia University
Start/End Date: July 1, 2014 – June 30, 2017
Amount Awarded to Date: $359,771

Funds development of a high-throughput system for engineering peptides that bind targets only in the presence of calcium, which can then be used for affinity purifications, with these peptides binding targets in the presence of calcium and then releasing them during the elution step upon the removal of calcium.

Title: Development of a Digital Ion Trap Mass Spectrometer for Resolved Mass Analysis of Intact Singly-Charged Proteins, Complexes, RNA, DNA, and Viruses
Principal Investigator: Peter Reilly
Sponsor: Washington State University
Start/End Date: June 1, 2014 – May 31, 2017
Amount Awarded to Date: $322,897

Funds development of a digital ion trap mass spectrometer with a mass range of more than 10 billion units for the observation and quantitative measurement of large biological molecules and complexes.

Title: Evaluation of New Nanomaterials as Sensing Agents Using a Charge-based Separation Technique
Principal Investigator: Leona Sirkisoon
Sponsor: Leona Sirkisoon
Start/End Date: June 1, 2014 – May 31, 2015
Amount Awarded to Date: $5,070

Funds development of graphene-based quantum dots as chemical modifiers in capillary electrophoresis to allow faster and easier detection of analytes including proteins.

Title: An Integrated Microfluidic Platform for Parallel Analysis of Cell Secretome and Cell Responses in Real Time
Principal Investigators: Jiang Zhe, Ge Zhang
Sponsor: University of Akron
Start/End Date: May 15, 2014 – April 30, 2017
Amount Awarded to Date: $172,103

Funds development of a microfluidic instrument consisting of a thermo-responsive culture chamber for rapid cell detachment without sample contamination, an immuno-disaggregation assay for analysis of cell secretomes, and a label-free magnetic bead assay for analyzing various cell responses to stimuli.

Title: A General Method to Map Protein Phosphorylation Networks
Principal Investigator: Steven Briggs
Sponsor: University of California, San Diego
Start/End Date: May 15, 2014 – April 30, 2016
Amount Awarded to Date: $300,000

Funds development of methods for mapping enzyme-substrate relationships for protein kinases and phosphatases.

Title: Development of Fluorescence-based Nanosensors for Dynamic Measurement of Active Cytokinins in Plants
Principal Investigators: George Schaller, Joseph Kieber, Sakiko Okumoto
Sponsor: Dartmouth College
Start/End Date: April 15, 2014 – March 31, 2016
Amount Awarded to Date: $290,808

Funds development of fluorescence-based nanosensors for in vivo detection of plant cytokinin levels.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.