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Funding Update: NSF Grants Awarded to Columbia University; Colorado State; and More

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Recent NSF Awards in Proteomics and Protein Research

Title: High-Bandwidth, Single-Molecule Bioelectronics Using a Multiplexed, Field-Effect Sensing Platform
Principal Investigators: Kenneth Shepard; Colin Nuckolls; Ruben Gonzalez
Sponsor: Columbia University
Start/End Date: July 1, 2012 – June 30, 2015
Amount Awarded to Date: $131,543

Funds the development of charge-based field-effect-transistor electronic single-molecule methods for analysis of biomolecular interactions, with a particular focus on studies of nucleic acid and protein interactions that could benefit from improved temporal resolution.


Title: Determining the Function of O-GlcNAc Protein Modification in Signal Transduction
Principal Investigator: Neil Olszewski
Sponsor: University of Minnesota-Twin Cities
Start/End Date: May 1, 2012 – April 30, 2015
Amount Awarded to Date: $576,000

Funds an effort to optimize mass spec-based methods for identifying O-GlcNAc-modified proteins and their modification sites in Arabidopsis thaliana with the larger aim of studying the effects of growth conditions on this modification and identifying signaling networks affected by the modification.


Title: Regulation of Chromatin-associated Proteins by Ubiquitin Modification of Histones H2A and H2B
Principal Investigator: Tingting Yao
Sponsor: Colorado State University
Start/End Date: May 1, 2012 – April 30, 2015
Amount Awarded to Date: $200,000

Funds development of methods to obtain chemically homogenous ubiquitin-H2A to identify proteins whose interactions with chromatin are regulated by ubiquitin and to characterize the potential interactions between ubiquitin and histones.

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