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Funding Update: NSF Grants Awarded to Boston University, Wright State, and More


Recent NSF Awards in Proteomics and Protein Research

Title: Intrinsic Oscillations in Supramolecular Assemblies: Novel Ultra-High Sensitivity Protein and Virus Detection
Principal Investigators: Elliott Brown, Peter Ortoleva, Edgar Mendoza
Sponsor: Wright State University
Start/End Date: Oct. 1, 2013 – Sept. 30, 2016
Amount Awarded to Date: $625,500

Funds an effort to study biological systems displaying autonomous oscillations with study aims including identification of autonomous oscillations in virus-like particles and the development of methods for detection of proteins and virus-like particles.

Title: Multiplexed Diagnostic Platform for Rapid Diagnostics
Principal Investigator: David Freedman
Sponsor: Boston University
Start/End Date: Oct. 1, 2013 – March 31, 2014
Amount Awarded to Date: $50,000

Funds an effort to develop a diagnostic platform based on interferometric reflectance imaging for the detection of proteins and nucleic acids at the single molecule level in whole blood and serum.

Title: Acquisition of a High Resolution LC-MS/MS System for Research and Education
Principal Investigators: Christopher Mulligan, Rachel Bowden, Michael Byrns, T. Mitchell, Brian Brennan
Sponsor: Illinois State University
Start/End Date: Sept. 15, 2013 – Aug. 31, 2016
Amount Awarded to Date: $399,981

Funds acquisition of an LC-MS/MS mass spectrometer for purposes including study of enzyme phosphocholine cytidylyltransferase, molecular mechanisms regulating cytoskeleton organization in plant cells, and roles of microtubule-associated proteins in plant cell expansion.

Title: Acquisition of a MALDI-TOF Mass Spectrometer
Principal Investigator: Mark Grinstaff
Sponsor: Boston University
Start/End Date: Sept. 15, 2013 – Aug. 31, 2016
Amount Awarded to Date: $115,423

Funds the acquisition of a MALDI-TOF mass spectrometer for applications including the study of inhibitors and activators of protein-protein interactions.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.