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Funding Update: Jul 16, 2009

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Recent NSF Awards in Proteomics and Protein Research

Title : A Proteomic Analysis of Stress Responses in the Ribbed Salt Marsh Mussel, Geukensia demissa
Principal Investigator : Peter Fields
Sponsor : Franklin and Marshall College
Start/End Date : July 15, 2009 – June 30, 2012
Award Amounted to Date : $209,151

The research will use proteomics to examine how the salt marsh mussel responds to environmental stress. The mussel, whose habitat extends from northern Florida to the Gulf of St. Lawrence, serves an important role in this environment, helping to stabilize sediment, filter particulates from the water, and provide habitat for many invertebrate species. The research will look at the biochemical strategies employed by the mussel to survive.


Title : Label-free Protein Arrays Based on Linear Dendron Macromolecular Layers and In Situ Real Time EC-SPR-AFM Methods
Principal Investigator : Rigoberto Advincula
Sponsor : University of Houston
Start/End Date : July 1, 2009 – June 30, 2012
Award Amounted to Date : $300,000

The research is directed at designing new protein arrays, focusing on "a new series of molecules based on electropolymerizable polyethylene glycol linear dendron layers for protein capture arranged as a layer by self-assembly Langmuir-Blodgett techniques and patterned on a surface," according to the abstract. Electrochemistry, surface plasmon resonance, and atomic force microscopy will be employed to develop array technology that enables live and real-time proteomics analysis. "Together with the combined multi-instrument mode studies and dip-pen nanoscale lithography, this will enable unprecedented control for proteomics array studies from micron- to nano-scale," the researchers said in the abstract.


Title : A Metal-free Surface for Label-free Array Detection
Principal Investigator : Voula Kodoyianni
Sponsor : GWC Technologies
Start/End Date : July 1, 2009 – Dec. 31, 2009
Award Amounted to Date : $100,000

Funds development of a proprietary "carbon-on-metal" technology to create protein arrays. The arrays would utilize gold as a substrate, a material that offers potential advantages for protein arrays but also several limitations including "fragility, a tendency to denature proteins, and limited reusability," according to the abstract. The CoM technology would be used to manufacture substrates to address these limitations [see PM 07/09/09].


Title : Development and Manufacture of Multi-Functional Materials and Structures
Principal Investigator : Young Noh
Sponsor : Nanoptics
Start/End Date : July 1, 2009 – June 30, 2010
Award Amounted to Date : $150,000

Funds the research and development of "continuous micro-stereo lithography as an enabling manufacturing platform of biocompatible, multifunctional material structures and systems such as plastic fiber microarray plates," according to the abstract. The plates offer "important" advantages over glass fiber microarray plates, including cost. The manufacturing cost of plastic fiber array plates have been shown to be an order of magnitude less than for glass microarrays, the researchers said. The plastic optical fiber arrays will also have .1 micron position alignment, compared to a few microns for glass fibers.


Title : Mass Spectrometry and Computational Studies of Deprotonated Peptides and Amino Acid Amides
Principal Investigator : Carolyn Cassady
Sponsor : University of Alabama
Start/End Date : July 1, 2009 – June 30, 2012
Award Amounted to Date : $470,000

Supports the work of Carolyn Cassady and David Dixon at the university "aimed at enhanced understanding of the gas-phase chemistry of deprotonated amino acid amides and peptides, in order ultimately to provide new approaches to mass spectrometric structure elucidation supporting proteomics and related studies," according to the abstract.

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