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Funding Update: Aug 12, 2011


Recent NSF Awards in Proteomics and Protein Research

Title: Design of Actibodies For Triggered Recognition
Principal Investigator: Wendy Thomas
Sponsor: University of Washington
Start/End Date: Oct. 1, 2011 – Sept. 30, 2014
Amount Awarded to Date: $300,000

Funds the development of a library of regulated recognition proteins that can be triggered to bind or release an analyte on cue with the aim of enabling improved separation technologies, in vitro diagnostics, molecular imaging systems, and targeted therapeutics.

Title: In Vivo Detection of Protein-Protein Interactions
Principal Investigator: Casonya Johnson
Sponsor: Georgia State University Research Foundation
Start/End Date: Sept. 1, 2011 – Aug. 31, 2013
Amount Awarded to Date: $300,000

Funds work to develop a method to detect transient interactions among transcription factors within the nuclei of living animals beginning with known interactors and then moving to discover novel interaction partners.

Title: Molecular Basis of Positional Signaling in Arabidopsis Root Epidermal Development
Principal Investigator: John Schiefelbein
Sponsor: University of Michigan
Start/End Date: Sept. 1, 2011 – Aug. 31, 2012
Amount Awarded to Date: $360,000

Funds research into germin-like proteins, a newly discovered group of signaling molecules, which the awardees will analyze for their role in the formation and patterning of cells and tissues in plants.

Title: Vapor Treatment of Charged Droplets for Enhanced Electrospray Ionization Performance
Principal Investigator: Scott McLuckey
Sponsor: Purdue University
Start/End Date: Sept 1, 2011 – Aug. 31, 2014
Amount Awarded to Date: $390,000

Funds investigations to expand the analytical capabilities of mass spectrometry by novel approaches to gas-phase ion formation and transformation based on exposing charged droplets to reactive vapors.

Title: Acquisition of a Mass Spectrometer
Principal Investigators: Michael Carrasco, Amelia Fuller
Sponsor: Santa Clara University
Start/End Date: Aug. 15, 2011 – July 31, 2014
Amount Awarded to Date: $159,159

Funds the acquisition of an electrospray ionization tandem mass spectrometer for use in areas including glycoprotein research and aptamers development.

Title: Evaluating Small Sugars as Recognition Molecules for the Detection of Abeta in Alzheimer's Disease
Principal Investigator: James Henry
Sponsor: Louisiana State University & Agricultural and Mechanical College
Start/End Date: Aug. 15, 2011 – July 31, 2012
Amount Awarded to Date: $20,000

Funds the development of carbohydrate biorecognition molecules to be used for in vivo and in vitro detection of forms of beta amyloid in support of development of methods of diagnosing and tracking progression of Alzheimer's disease.

Title: Development of SPR Phase Imaging and SPR Diffraction Methods for Ultrasensitive Microarray Biosensing
Principal Investigator: Robert Corn
Sponsor: University of California-Irvine
Start/End Date: Aug. 15, 2011 – July 31, 2014
Amount Awarded to Date: $468,250

Supports efforts to develop new instrumentation and methodologies for the label-free detection of biologically relevant molecules, including proteins, at low concentrations using surface plasmon resonance phase imaging and optical diffraction methods from nanowire arrays, nanogaps, and nanostructured surfaces.

Title: Micro-Patterned SPR Chips for Multiplexed Imaging Analysis of Arrays
Principal Investigator: Quan Cheng
Sponsor: University of California-Riverside
Start/End Date: Aug. 15, 2011 – July 31, 2014
Amount Awarded to Date: $390,000

Funds work on developing improved surface plasmon resonance sensing and imaging techniques for the study of biomolecular interactions.

Title: Acquisition of LC-MS/MS Instrumentation for Undergraduate Research and Education
Principal Investigators: Elizabeth Stemmler, Patsy Dickinson, Dharni Vasudevan, Danielle Dube, Benjamin Gorske
Sponsor: Bowdoin College
Start/End Date: Aug. 15, 2011 – July 31, 2014
Amount Awarded to Date: $379,944

Funds the purchase of an LC-MS/MS instrument for research including transcriptomics and peptidomics studies, characterization of bacterial glycosylation, and studies of protein methylation.

Title: A Self-Assembled Nano-Array Platform for Membrane Protein Sensors and Analytics
Principal Investigators: Donald Roper, Shannon Servoss
Sponsor: University of Arkansas
Start/End Date: Aug. 1, 2011 – July 31, 2014
Amount Awarded to Date: $330,000

Funds work on developing a self-assembling platform capable of detecting and analyzing membrane proteins with the aim of detecting biomarkers to diagnose disease, test drug efficacy, and advance understanding of cell functions.

Title: Si Nanoelectronic Femtosensor as Ultrasensitive, Label-Free, Protein -Based Molecular Diagnostic Platform
Principal Investigator: Walter Hu
Sponsor: University of Texas at Dallas
Start/End Date: Aug. 1, 2011 – July 31, 2013
Amount Awarded to Date: $300,000

Funds efforts to move biosensor technology developed at the University of Texas at Dallas toward commercialization by developing a prototype instrument and establishing proof-of-concept protein-based tests to demonstrate its potential as a portable and low-cost diagnostic platform.

The Scan

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.

Analysis of Endogenous Parvoviral Elements Found Within Animal Genomes

Researchers at PLOS Biology have examined the coevolution of endogenous parvoviral elements and animal genomes to gain insight into using the viruses as gene therapy vectors.

Saliva Testing Can Reveal Mosaic CNVs Important in Intellectual Disability

An Australian team has compared the yield of chromosomal microarray testing of both blood and saliva samples for syndromic intellectual disability in the European Journal of Human Genetics.

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.