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Funding Update: Jul 1, 2011

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Recent NSF Awards in Proteomics and Protein Research

Title: Electrophoresis in Liquid Crystals
Principal Investigator: Oleg Lavrentovich
Sponsor: Kent State University
Start/End Date: Sept. 1, 2011 – Aug. 31, 2013
Amount Awarded to Date: $290,000

Funds research on electrophoresis in liquid crystals for potential use in a variety of applications including multidimensional protein separations.


Title: Expanding Application of Proteomics-based Research in Archaeological Residue Analysis
Principal Investigator: Stanley Stevens
Sponsor: University of South Florida
Start/End Date: July 1, 2011 – Dec. 31, 2013
Amount Awarded to Date: $46,850

Funds burial experiments with modern cooking pottery and research on archaeological pottery to evaluate the role of variability in climate, soil, and ceramic paste on the preservation of food protein residues.


Title: Expanding Application of Proteomics-based Research in Archaeological Residue Analysis
Principal Investigator: Steve Wolverton, Barney Venables, Reid Ferring
Sponsor: University of North Texas
Start/End Date: July 1, 2011 – Dec. 31, 2013
Amount Awarded to Date: $97,393

Funds burial experiments with modern cooking pottery and research on archaeological pottery to evaluate the role of variability in climate, soil, and ceramic paste on the preservation of food protein residues.


Title: Development of Novel Dendrimer-based Technologies for Phosphorylation Analyses
Principal Investigator: Anton Iliuk
Sponsor: Tymora Analytical Operations
Start/End Date: July 1, 2011 – Dec. 31, 2011
Amount Awarded to Date: $150,000

Funds the development of a dendrimer-based platform for the study of protein phosphorylation – including general detection, inhibitor screening, kinase and phosphatase activity quantitation, and phosphopeptide enrichment – with the aim of overcoming current technological shortcomings including low reproducibility, high cost, reduced selectivity, and long experiment times.


Title: Integrative Bioinformatics for Knowledge Discovery of PTM Networks
Principal Investigators: Cathy Wu, Vijay Shanker, Jung-Youn Lee
Sponsor: University of Delaware
Start/End Date: July 1, 2011 – June 30, 2012
Amount Awarded to Date: $380,678

Funds the development of iPTMnet, a plant-specific bioinformatics resource for integrated understanding of plant protein post-translational modifications in a systems biology context.


Title: Cooperative Approaches for Aptamer Selection and Protein Detection
Principal Investigator: Christopher Easley
Sponsor: Auburn University
Start/End Date: July 1, 2011 – June 30, 2014
Amount Awarded to Date: $383,786

Funds efforts to use known antibodies and aptamers to find new aptamers in a random sequence library of single-stranded DNA and then use DNA-based experimental models to optimize the assay formats in which the aptamers are intended to be used.


Title: Deep Proteome Imaging System
Principal Investigator: Jonathan Minden
Sponsor: Carnegie-Mellon University
Start/End Date: June 1, 2011 – May 31, 2012
Amount Awarded to Date: $117,755

Funds the development of a structured illumination gel imager system that can quantify proteins over a million-fold concentration range – a more than 50-fold improvement over existing fluorescent gel imagers – to allow proteomics researchers to explore the proteome more deeply than is currently possible.


Title: Bridging the Gap between the Transcriptome and the Proteome to Study Inter-cellular Signaling
Principal Investigators: T. Murali, Richard Helm, Padmavathy Rajagopalan
Sponsor: Virginia Polytechnic Institute and State University
Start/End Date: June 1, 2011 – May 31, 2012
Amount Awarded to Date: $333,348

Funds the development of an approach to guiding proteomic experiments using data from transcriptional experiments based on novel algorithms for computing directed Steiner acyclic graphs. The researchers will use this approach to investigate inter-cellular signaling between two different types of hepatic cells.

The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.