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Funding Update: May 20, 2011

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Recent NSF Awards in Proteomics and Protein Research

Title: Integrative Bioinformatics for Knowledge Discovery of PTM Networks
Principle Investigator: Cathy Wu, Vijay Shanker, Jung-Youn Lee
Sponsor: University of Delaware
Start/End Date: July 1, 2011 – June 30, 2012
Amount Awarded to Date: $380,678

Funds the development of a bioinformatics research infrastructure for integrated understanding of plant post-translational modifications in a systems biology context. The work will integrate text mining, data mining, data analysis and visualization tools, and databases and ontologies into a research resource to explore and discover PTM networks.


Title: Diffusing Probes of kT-scale Specific Protein-Protein and Protein-Carbohydrate Interactions
Principle Investigator: Michael Bevan
Sponsor: Johns Hopkins University
Start/End Date: June 1, 2011 – May 31, 2012
Amount Awarded to Date: $106,334

Funds work using diffusing colloidal probe microscopy to measure the interactions of surface immobilized proteins and carbohydrates with the ultimate aim of developing capabilities for measuring weak interactions between proteins and carbohydrates on synthetic materials to enable various biomedical applications.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.