Title: Engineering Bacteriophage as Amplifiable Platforms for Analyte Sensing and Identification
Principal Investigator: Jennifer Cha
Sponsor: University of California-San Diego
Start/End Date: April 1, 2011 – March 31, 2012
Amount Awarded to Date: $91,555
Funds work investigating the use of the M13 bacteriophage virus as a platform for providing amplified, optically-detectable responses to the binding of biological analytes with the aim of developing a more stable alternative to protein-antibody sandwich assays.
Title: Assessing Biomarkers of Oil-Spill Weathering in the Air and Water at Impacted Louisiana Shorelines
Principal Investigator: Bernard Singleton
Sponsor: Dillard University
Start/End Date: Feb. 1, 2011 – Jan. 31, 2012
Amount Awarded to Date: $199,989
Funds a project to perform biomarker analysis of air, water, and sediments from shoreline impacted by the Horizon Well oil spill in the Gulf of Mexico. Particulate matter will be analyzed for total biological load including carbohydrates, proteins, phospholipids, and DNA and efforts will be undertaken to assess the effect hydrocarbons and dispersants from the spill have on the numbers of particles able to penetrate the human respiratory system and their potential toxicity.
Title: A Novel Approach for Deciphering Cellular Metabolic Phenotypes Using Tandem Mass Spectrometry
Principal Investigator: Maciej Antoniewicz
Sponsor: University of Delaware
Start/End Date: Feb. 1, 2011 – Jan. 31, 2016
Amount Awarded to Date: $400,004
Funds the use of tandem mass spectrometry to quantify the metabolic state of cells by measuring intracellular metabolic fluxes with the ultimate goal of developing a better understanding of cellular metabolism to allow manipulation of cell behavior.