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Funding Update: Feb 4, 2011

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Title: Engineering Bacteriophage as Amplifiable Platforms for Analyte Sensing and Identification
Principal Investigator: Jennifer Cha
Sponsor: University of California-San Diego
Start/End Date: April 1, 2011 – March 31, 2012
Amount Awarded to Date: $91,555

Funds work investigating the use of the M13 bacteriophage virus as a platform for providing amplified, optically-detectable responses to the binding of biological analytes with the aim of developing a more stable alternative to protein-antibody sandwich assays.


Title: Assessing Biomarkers of Oil-Spill Weathering in the Air and Water at Impacted Louisiana Shorelines
Principal Investigator: Bernard Singleton
Sponsor: Dillard University
Start/End Date: Feb. 1, 2011 – Jan. 31, 2012
Amount Awarded to Date: $199,989

Funds a project to perform biomarker analysis of air, water, and sediments from shoreline impacted by the Horizon Well oil spill in the Gulf of Mexico. Particulate matter will be analyzed for total biological load including carbohydrates, proteins, phospholipids, and DNA and efforts will be undertaken to assess the effect hydrocarbons and dispersants from the spill have on the numbers of particles able to penetrate the human respiratory system and their potential toxicity.


Title: A Novel Approach for Deciphering Cellular Metabolic Phenotypes Using Tandem Mass Spectrometry
Principal Investigator: Maciej Antoniewicz
Sponsor: University of Delaware
Start/End Date: Feb. 1, 2011 – Jan. 31, 2016
Amount Awarded to Date: $400,004

Funds the use of tandem mass spectrometry to quantify the metabolic state of cells by measuring intracellular metabolic fluxes with the ultimate goal of developing a better understanding of cellular metabolism to allow manipulation of cell behavior.

The Scan

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.

Fragile X Syndrome Mutations Found With Comprehensive Testing Method

Researchers in Clinical Chemistry found fragile X syndrome expansions and other FMR1 mutations with ties to the intellectual disability condition using a long-range PCR and long-read sequencing approach.

Team Presents Strategy for Speedy Species Detection in Metagenomic Sequence Data

A computational approach presented in PLOS Computational Biology produced fewer false-positive species identifications in simulated and authentic metagenomic sequences.

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.