Recent NSF Awards in Proteomics and Protein Research
Title: A Toolbox for Protein Sample Pretreatment
Principal Investigator: Frank Jahnke
Sponsor: Sonata Biosciences
Start/End Date: Jan. 1, 2011 – June 30, 2011
Amount Awarded to Date: $150,000
Funds work to test the feasibility of a “toolbox” designed to pretreat complex protein samples to prepare them for proteomic analysis. The platform allows sequential manipulation of the initial samples without need for physical transfer from one operation to the next, potentially increasing reliability of the sample-prep process while decreasing sample loss and risk of contamination.
Title: Novel Microarray Platforms for Detection of Rare Molecules in Complex Mixtures
Principal Investigator: Michael Harvey
Sponsor: Maine Manufacturing
Start/End Date: Jan. 1, 2011 – June 30, 2011
Amount Awarded to Date: $149,499
Funds the development of a microarray with high protein binding capability to improve fluorescence detection. By using a nitrocellulose membrane modified by functional silanes to allow covalent coupling of proteins and nucleic acids, the researchers hope to create conditions where the capture molecules can be immobilized at a sufficient density to provide a sensitive assay surface.