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Funding Update: Nov 19, 2010 (rev. 1)

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Recent NSF Awards in Proteomics and Protein Research

Title: Learning in Worst-Case Noise Models
Principal Investigator: Adam Klivans
Sponsor: University of Texas at Austin
Start/End Date: Sept. 1, 2011 – Aug 31, 2014
Amount Awarded to Date: $499,864

Funds a study to develop machine-learning algorithms that can succeed in the presence of noisy datasets, which could lead to more powerful classification tools for purposes such as protein identification and detection.


Title: Development of Fluorescent Probes for Protein Phosphorylation
Principal Investigator: Hung-Teh Kao
Sponsor: Lucidicor
Start/End Date: Jan. 1, 2011 – June 30, 2011
Amount Awarded to Date: $150,000

Funds a project to optimize and market a fluorescent biomarker responsive to protein phosphorylation that could be used in the detection of protein kinase activity, allowing for better study of protein signaling networks as well as screening for pharmaceutical compounds like kinase inhibitors.


Title: Enzymology of Multi-Enzyme Systems on Self-Assembled Surfaces
Principal Investigator: Neal Woodbury
Sponsor: Arizona State University
Start/End Date: Dec. 1, 2010 – Nov. 30, 2013
Amount Awarded to Date: $406,206

Funds research into using ligands and self-assembled DNA nanoscaffold surfaces to optimize the orientations and conformations of surface-bound enzymes to improve their function in various biosensing and biocatalytic applications.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.