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Funding Update: Sep 3, 2010 (rev. 1)


Recent NSF Awards in Proteomics and Protein Research

Title: MRI: Acquisition of a SELDI ProteinChip Reader
Principal Investigator: Wei Yin, David Rubenstein
Sponsor: Oklahoma State University
Start/End Date: Nov. 1, 2010 – Oct. 31, 2013
Amount Awarded to Date: $178,139

Funds the acquisition of a SELDI ProteinChip reader for studying proteomics, protein interactions, and enzymatic kinetic reactions. In particular, the device will be used to facilitate studies into biomarkers and protein-protein interactions.

Title: BRIDGE: Microfractionation in Droplets (µFD) - Linking Proteomic Separations to High-Throughput Functional Screening
Principal Investigator: Amar Basu
Sponsor: Wayne State University
Start/End Date: Sept. 1, 2010 – Aug. 31, 2012
Amount Awarded to Date: $174,983

The project seeks to develop highly scalable fractionation technology for whole-proteome functional screening using microscale droplets to collect and isolate thousands of isolated protein fractions. The researchers aim to build a system to integrate microfractionation with size exclusion chromatography, form a protein library using SEC-iFD, and use this protein library in a model enzyme screening assay.

Title: Applications of Biomolecular Ion Photofragmentation
Principal Investigator: James Reilly
Sponsor: Indiana University
Start/End Date: Sept. 1, 2010 – Aug. 31, 2011
Amount Awarded to Date: $140,000

Funds an investigation into the use of photofragmentation by high-energy ultraviolet light to improve the structural analysis of peptides via mass spectrometry. The study will examine the photofragmentation process to better understand its variability in order to provide a more effective approach for protein identification.

Title: Variable Selection Methods in High Dimensional Feature Space
Principal Investigator: Rui Song
Sponsor: Colorado State University
Start/End Date: Sept. 1, 2010 – Aug. 31, 2013
Amount Awarded to Date: $100,000

Funds research into the development of statistical theory and methods for high dimensional variable selections, which are increasingly needed for the analysis of high-throughput data produced in fields like proteomics.

Title: Phosphotyrosine-dependent regulatory mechanisms of mammalian brain development: A large-scale phosphoproteomic and biochemical study.
Principal Investigator: Bryan Ballif
Sponsor: University of Vermont & State Agricultural College
Start/End Date: Aug. 15, 2010 – July 31, 2011
Amount Awarded to Date: $132,005

The study will use proteomic techniques to examine proteins known to be essential to neuronal positioning in order to better understand how neurons of the mammalian brain are positioned during development. In particular, the research will focus on the role of tyrosine phosphorylation of proteins critical to brain development.

The Scan

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.

Adenine Base Editor Targets SCID Mutation in New Study

Researchers from the University of California, Los Angeles, report in Cell that adenine base editing was able to produce functional T lymphocytes in a model of severe combined immune deficiency.

Researchers Find Gene Affecting Alkaline Sensitivity in Plants

Researchers from the Chinese Academy of Science have found a locus affecting alkaline-salinity sensitivity, which could aid in efforts to improve crop productivity, as they report in Science.

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.