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Funding Update: Aug 13, 2010

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NIH Grants in Proteomics, June 26 to Aug. 5, Part 2 of 2

Title: Mass Spectrometry of Protein Assemblies
Contact Principal Investigator: Joseph Loo
Organization: University of California Los Angeles
Project Start Date: July 15, 2004
Project End Date: June 30, 2013
FY Total Cost by IC: $378,210


Title: Differential Mapping of Posttranslational Modifications in Tumor Cells
Contact Principal Investigator: David Lubman
Organization: University of Michigan at Ann Arbor
Project Start Date: Sept. 12, 1994
Project End Date: July 31, 2011
FY Total Cost by IC: $264,115


Title: Typhoid Priority Antigen Identification and Vaccine Development
Contact Principal Investigator: Stephen McSorley
Organization: University of Minnesota Twin Cities
Project Start Date: Aug. 20, 2008
Project End Date: July 31, 2012
FY Total Cost by IC: $347,356


Title: Typhoid Priority Antigen Identification and Vaccine Development
Contact Principal Investigator: Stephen McSorley
Organization: University of Minnesota Twin Cities
Project Start Date: Aug. 20, 2008
Project End Date: July 31, 2012
FY Total Cost by IC: $182,835


Title: Identification of Altered Glycan and Glycoproteins in Viral Induced Liver Cancer
Contact Principal Investigator: Anand Mehta
Organization: Drexel University
Project Start Date: Sept. 26, 2006
Project End Date: July 31, 2011
FY Total Cost by IC: $332,149


Title: Identification of Colon Cancer Protein Biomarkers in the Blood
Contact Principal Investigator: Wilfrido Diokno Mojica
Organization: State University of New York at Buffalo
Project Start Date: Aug. 15, 2009
Project End Date: July 31, 2011
FY Total Cost by IC: $79,250


Title: Protein Biomarkers for a New Human Polyomavirus in AIDS-Related Malignancies
Contact Principal Investigator: Patrick Moore
Organization: University of Pittsburgh at Pittsburgh
Project Start Date: Sept. 25, 2008
Project End Date: July 31, 2011
FY Total Cost by IC: $340,875


Title: A Collaboration Platform for Proteomics Biomarker Analysis
Contact Principal Investigator: Erik Nilsson
Organization: Insilicos
Project Start Date: Jan. 8, 2005
Project End Date: June 30, 2011
FY Total Cost by IC: $83,179


Title: Redox Mediated Signaling in the Toll-Like Receptor Family
Contact Principal Investigator: Fredrick Oakley
Organization: University of Iowa
Project Start Date: Aug. 1, 2007
Project End Date: July 31, 2011
FY Total Cost by IC: $34,360


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Title: A Metabolomic Search for Endogenous Chemical Agonists of Nociceptive TRP Channels
Contact Principal Investigator: Ardem Patapoutian
Organization: Scripps Research Institute
Project Start Date: July 15, 2010
Project End Date: June 30, 2012
FY Total Cost by IC: $284,850


Title: Improve Predictions of Structure and Function by PredictProtein
Contact Principal Investigator: Itshack Pe'er
Organization: Columbia University
Project Start Date: April 1, 2002
Project End Date: April 30, 2011
FY Total Cost by IC: $327,180


Title: Fluorescent Cellular Zinc Sensors. What Are They Imaging?
Contact Principal Investigator: David Harold Petering
Organization: University of Wisconsin Milwaukee
Project Start Date: Sept. 1, 2008
Project End Date: July 31, 2012
FY Total Cost by IC: $281,309


Title: Proteomic Profiling of NASH: Disease Mechanisms and Novel Treatment
Contact Principal Investigator: Dennis Petersen
Organization: University of Colorado Denver
Project Start Date: Sept. 1, 2007
Project End Date: July 31, 2012
FY Total Cost by IC: $303,876


Title: Novel Photoreceptor Cilia Proteins and Retinal Degenerations
Contact Principal Investigator: Eric Pierce
Organization: University of Pennsylvania
Project Start Date: July 8, 1999
Project End Date: July 31, 2013
FY Total Cost by IC: $524,862


Title: Crossprotective CTL Against Influenza
Contact Principal Investigator: Ellis Reinherz
Organization: Dana-Farber Cancer Institute
Project Start Date: July 12, 2010
Project End Date: June 30, 2011
FY Total Cost by IC: $1,500,000


Title: Metabolomic and Integromic Approaches to Identify Fingerprints for Early Detection
Contact Principal Investigator: Habtom Ressom
Organization: Georgetown University
Project Start Date: July 1, 2010
Project End Date: June 30, 2012
FY Total Cost by IC: $200,318


Title: Quantitative Analysis of LC-MS Data for Peptide and Glycan Biomarker Discovery
Contact Principal Investigator: Habtom Ressom
Organization: Georgetown University
Project Start Date: Aug. 1, 2010
Project End Date: July 31, 2015
FY Total Cost by IC: $268,625


Title: Analysis of B Cell Receptor Signals Modified by Mercury
Contact Principal Investigator: Allen Rosenspire
Organization: Wayne State University
Project Start Date: July 15, 2010
Project End Date: June 30, 2012
FY Total Cost by IC: $228,000


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Title: Single-Molecule Mass Spectrometry Enabled By Nanomechanical Systems (NEMS-MS)
Contact Principal Investigator: Michael Roukes
Organization: California Institute Of Technology
Project Start Date: Aug. 14, 2009
Project End Date: July 31, 2011
FY Total Cost by IC: $527,246


Title: Forecasters of Futute and Progressive CDK in Patients with Microvascular Glomerul
Contact Principal Investigator: Jon Klein
Organization: Ohio State University
Project Start Date: Sept. 30, 2009
Project End Date: April 30, 2014
FY Total Cost by IC: $365,321


Title: Towards a Molecular Signature of Neutrophil Priming
Contact Principal Investigator: Arthur Robert Salomon
Organization: Brown University
Project Start Date: July 17, 2009
Project End Date: June 30, 2011
FY Total Cost by IC: $229,166


Title: The Role of Aquaporin-0 in Lens Development and Aging
Contact Principal Investigator: Kevin L Schey
Organization: Vanderbilt University
Project Start Date: May 1, 2001
Project End Date: July 31, 2011
FY Total Cost by IC: $306,651


Title: Secretome Proteomics for VHL Tumor Biomarker Discovery
Contact Principal Investigator: Yuzuru Shiio
Organization: University of Texas Health Center San Antonio
Project Start Date: Aug. 1, 2009
Project End Date: July 31, 2011
FY Total Cost by IC: $163,350


Title: Proteomic Evaluation of the Blood-Brain Barrier Receptor-Mediated Transportome
Contact Principal Investigator: Eric Shusta
Organization: University of Wisconsin Madison
Project Start Date: Aug. 1, 2010
Project End Date: May 31, 2014
FY Total Cost by IC: $289,240


Title: Discovery and Validation of Novel Serological Biomarkers of Colon Cancer
Contact Principal Investigator: David Speicher
Organization: Wistar Institute
Project Start Date: Sept. 29, 2006
Project End Date: July 31, 2011
FY Total Cost by IC: $386,939


Title: Dissecting Ubiquitin Pathway Selectivity with Ub-Isopeptide Microarrays
Contact Principal Investigator: James Strickler
Organization: Lifesensors, Inc.
Project Start Date: Aug. 1, 2010
Project End Date: July 31, 2011
FY Total Cost by IC: $278,218


Title: The Comprehensive Discovery and Assay of the Human Proteome
Contact Principal Investigator: Mark Chlenov
Organization: Differential Proteomics, Inc.
Project Start Date: Sept. 15, 2009
Project End Date: June 30, 2011
FY Total Cost by IC: $286,945


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Title: Mass Spectrometry of Proteins Involved in Organogenesis (5 of 10)
Contact Principal Investigator: Shamil Sunyaev
Organization: Brigham and Women's Hospital
Project Start Date: Sept. 28, 2007
Project End Date: June 30, 2012
FY Total Cost by IC: $379,466


Title: New Proteomic Algorithms to Identify Mutant or Modified Proteins
Contact Principal Investigator: David Lee Tabb
Organization: Vanderbilt University
Project Start Date: Sept. 27, 2006
Project End Date: July 31, 2011
FY Total Cost by IC: $297,369


Title: Development of Technology for High Resolution Epigenetic Profiling of Chromatin
Contact Principal Investigator: Alan Jackson Tackett
Organization: University of Arkansas for Medical Sciences
Project Start Date: Sept. 20, 2008
Project End Date: July 31, 2012
FY Total Cost by IC: $382,388


Title: Multiplex Serodiagnostic Test for Chagas Disease
Contact Principal Investigator: Rick Tarleton
Organization: University of Georgia
Project Start Date: Aug. 2, 2010
Project End Date: July 31, 2011
FY Total Cost by IC: $782,492


Title: TNF-Alpha in Cell Death & Neuroprotection in Glaucoma
Contact Principal Investigator: Gulgun Tezel
Organization: University of Louisville
Project Start Date: Dec. 1, 2001
Project End Date: July 31, 2012
FY Total Cost by IC: $329,670


Title: Post-Transcriptional Regulation of Virulence in Campylobacter Jejuni
Contact Principal Investigator: Stuart Thompson
Organization: Medical College of Georgia
Project Start Date: July 19, 2010
Project End Date: July 18, 2011
FY Total Cost by IC: $327,900


Title: Post-Translational Regulation of Embryonic Stem Cells: A Proteomic Study.
Contact Principal Investigator: Jennifer Van Eyk
Organization: Johns Hopkins University
Project Start Date: July 1, 2009
Project End Date: June 30, 2011
FY Total Cost by IC: $403,025


Title: Novel Method to Identify Competing Protein-Protein Binders
Contact Principal Investigator: Mikhail Veshtort
Organization: Columbia University Health Sciences
Project Start Date: Aug. 1, 2009
Project End Date: July 31, 2011
FY Total Cost by IC: $80,500


Title: Analysis of the Proteome of PKD-ELVS in Polycystic Kidney Disease and Controls
Contact Principal Investigator: Marie Hogan
Organization: Mayo Clinic
Project Start Date: Sept. 30, 2009
Project End Date: July 31, 2011
FY Total Cost by IC: $473,836


Title: Proteomic Approaches to Protein Fatty Acylation
Contact Principal Investigator: Julian P Whitelegge
Organization: University of California Los Angeles
Project Start Date: Aug. 15, 2009
Project End Date: July 31, 2011
FY Total Cost by IC: $285,863


Title: Characterization Methodologies & Proteomics to Assess Carbon Nanotube Exposure
Contact Principal Investigator: Somenath Mitra
Organization: Indiana University-Purdue University at Indianapolis
Project Start Date: Sept. 25, 2009
Project End Date: June 30, 2011
FY Total Cost by IC: $599,000

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.