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Funding Update for Jul 30, 2010


Recent NSF Awards in Proteomics and Protein Research

Title: Electronic Allergy Diagnostics: Photo-Immobilization as a General Strategy for Attaching Structurally and Compositionally Diverse Ligands onto a Single Support
Principal Investigator: Brian Clare
Sponsor: Virogenomics
Start/End Date: July 1, 2010 – Dec. 31, 2010
Amount Awarded to Date: $149,993

The project will look at the feasibility of using photochemical linkers to immobilize small molecules, synthetic peptides, purified proteins, and crude natural extracts on electrochemical sensor arrays. The research seeks to develop a single photochemical protocol for preparing the various assays, enabling the manufacture of highly multiplexed sensor arrays for use in point-of-care diagnostics.

Title: Nanoscopic Understanding of Protein Transport and Structure Dynamics in Charged Gels for Protein Chromatography
Principal Investigator: Giorgio Carta, Michael Shirts
Sponsor: University of Virginia Main Campus
Start/End Date: Aug. 15, 2010 – July 31, 2013
Amount Awarded to Date: $303,000

Funds a study to investigate the movement of proteins in charged gels for the development of new matrices for protein chromatography. The research will look at the structure and dynamic behavior of dextran-grafted matrices and the movement of individual proteins in these matrices at the nanoscopic scale.

Title: Surface-Initiated Enzymatic Polymerization of DNA Nanostructures for Highly Amplified Sensing
Principal Investigator: Ashutosh Chilkoti, Stefan Zauscher
Sponsor: Duke University
Start/End Date: Sept. 1, 2010 – Aug. 31, 2013
Amount Awarded to Date: $360,000

Funds research to use surface-initiated enzymatic polymerization, or SIEP, of DNA to develop a new on-chip signal detection and amplification system that is broadly applicable to a variety of multiplexed molecular detection schemes, including on-chip sensors, heterogeneous immunoassays, and protein microarrays.

Title: Large Scale Microtubule-Based Nanomanufacturing of Single Kinesin Patterns with Ultrahigh Resolution
Principal Investigator: Douglas Chrisey, Zoica Cerasela Dinu
Sponsor: Rensselaer Polytechnic Institute, West Virginia University Research Corporation
Start/End Date: Sept. 1, 2010 – Aug. 31, 2011
Amount Awarded to Date: $50,000

The project seeks to develop single protein nanoarrays based on self-assembly and self-recognition for use in areas such as nanosensors, screening, drug delivery, and as a proof of principle that biological molecules can be used for printing ultrahigh-resolution nanoarrays.

The Scan

Pfizer-BioNTech Seek Full Vaccine Approval

According to the New York Times, Pfizer and BioNTech are seeking full US Food and Drug Administration approval for their SARS-CoV-2 vaccine.

Viral Integration Study Critiqued

Science writes that a paper reporting that SARS-CoV-2 can occasionally integrate into the host genome is drawing criticism.

Giraffe Species Debate

The Scientist reports that a new analysis aiming to end the discussion of how many giraffe species there are has only continued it.

Science Papers Examine Factors Shaping SARS-CoV-2 Spread, Give Insight Into Bacterial Evolution

In Science this week: genomic analysis points to role of human behavior in SARS-CoV-2 spread, and more.