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Funding Update: Jul 9, 2010

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Recent NSF Awards in Proteomics and Protein Research

Title: Microfluidic Devices for Enhancing the Sensitivity of ELISA methods
Principal Investigator: Debashis Dutta, Robert Corcoran
Sponsor: University of Wyoming
Start/End Date: July 1, 2010 – June 30, 2011
Amount Awarded to Date: $187,868

Funds a project to develop microfluidic devices that increase ELISA sensitivity by entrapping target molecules in a trapping zone with a volume on the order of nanoliters or less, leading to a large concentration of molecules and increased sensitivity. The project also plans to apply this technology to the simultaneous detection of two analytes.


Title: Structural Interpretation of the Protein Interactome
Principal Investigator: Robert Jernigan, Andrzej Kloczkowski
Sponsor: Iowa State University
Start/End Date: Aug. 1, 2010 – July 31, 2011
Amount Awarded to Date: $138,994

Funds a project to combine protein structural modeling with collected data on protein-protein interactions in order to develop a better understanding of this data. The study aims to test interaction data and discover missing interactions as well as develop molecular models for most pairs of protein-protein interactions. Validation of some newly predicted interactions will be carried out using mass spectrometry.


Title: Metal Phosphonate Interfaces for Phosphopeptide Enrichment
Principal Investigator: Daniel Talham
Sponsor: University of Florida
Start/End Date: July 1, 2010 – June 30, 2013
Amount Awarded to Date: $392,500

The project will explore metal phosphate and metal phosphonate solids and thin films as a new class of phosphopeptide separation and enrichment media. These enrichment systems will be tested for applicability to mass spectrometry analysis of phosphopeptides.


Title: 2010 Intrinsically Disordered Proteins Gordon Research Conference
Principal Investigator: Vladimir Uversky, A. Keith Dunker, Nancy Ryan Gray
Sponsor: Gordon Research Conferences
Start/End Date: July 1, 2010 – Dec. 31, 2010
Amount Awarded to Date: $10,000

The proposal seeks to fund a new Gordon Research Conference focusing on intrinsically disordered proteins, or IDPs – functional proteins without unique 3D structures. IDPs constitute a functionally broad portion of many organisms' proteomes and are the locations for many signaling sequences and posttranslational modification sites, according to the abstract.


Title: Photodissociation and Ion Trap Mass Spectrometry
Principal Investigator: Jennifer Brodbelt
Sponsor: University of Texas at Austin
Start/End Date: Sept. 1, 2010 – Aug. 31, 2013
Amount Awarded to Date: $486,000

The award will fund the development of photodissociation and chemical derivatization methods that add chromophores and/or charge sites to molecules in order to modify ion fragmentation patterns to enable improved mass spectrometry analysis and structural characterization of biological molecules such as peptides, proteins, carbohydrates, and nucleic acids.

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