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Funding Update: Feb 19, 2010


Recent NSF Awards in Proteomics and Protein Research

Title: Quantitative Mass Spectrometry Analysis of Histone Codes in Saccharomyces cerevisiae
Principal Investigator: Benjamin Garcia
Sponsor: Princeton University
Start/End Date: April 1, 2010 – March 31, 2011
Amount Awarded to Date: $205,000

Research funded by the award will be directed toward the development of mass spectrometry-based proteomic methods and bioinformatics "to quantitatively characterize combinatorial histone modification patterns and their influence on gene expression under different biological conditions in yeast," according to the abstract.

Title: ABRF2010 Satellite Educational Workshops held on March 20, 2010 in Sacramento CA
Principal Investigators: Katia Sol-Church; Karen Jonscher: Michael Zianni
Sponsor: Alfred I du Pont Hospital for Children
Start/End Date: Feb. 1, 2010 – Jan. 31, 2011
Amount Awarded to Date: $46,000

Supports five educational workshops to be held before the start of this year's Association of Biomolecular Resource Facilities annual meeting next month. Specifically, the funding is for 25 scholarships for undergraduates, graduate students, post-doc follows, and core personnel to attend the workshops, which include one called Introduction to Proteomics Platforms: Applications for Qualitative and Quantitative Studies, and another called Targeted Proteomics. The other workshops are directed toward RNA research; next-generation DNA sequencing; and managing performance and productivity in the laboratory.

Title: Acquisition of a Triple Quadrupole Mass Spectrometer
Principal Investigators: Michael Chiarelli; Nancy Tuchman; Pamela Geddes
Sponsor: Loyola University of Chicago
Start/End Date: Feb. 1, 2010 – Jan. 31, 2011
Amount Awarded to Date: $355,703

Funds the acquisition of a triple quadrupole mass spec with UPLC system. The instrument will be used for research conducted at the university's Center for Urban Environmental Research & Policy to study "emergent contaminants found in natural aquatic ecosystems" in and around Chicago, according to the abstract. The award also funds the study of phosphorylation in proteins implicated in triggering

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.