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Funding Update: Jan 29, 2010

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Recent NSF Awards in Proteomics and Protein Research

Title: Acquisition of an LC-MS System to Enhance Undergraduate Research That Interfaces Chemistry and Biology
Principal Investigators: Kevin Minbiole; Daniel Downey; Reid Harris; Debra Mohler; Gina MacDonald
Sponsor: James Madison University
Start/End Date: Jan. 15, 2010 – Dec. 31, 2012
Amount Awarded to Date: $299,810

Supports the purchase of an LC-MS platform to, among other things, characterize anti-fungal metabolites from the skin bacteria of frogs and salamanders; study interactions between DNA and chromatin; and measure neurotransmitter metabolites in blood.


Title: Acquisition of a High Resolution Q-TOF Mass Spectrometer
Principal Investigators: Jim Lawrence ; John Droske; Nathan Bowling; Don Guay
Sponsor: University of Wisconsin-Stevens Point
Start/End Date: Jan. 15, 2010 – Dec. 31, 2010
Amount Awarded to Date: $469,942

Funds the purchase of an LC-Q-TOF system. Currently, seven research projects are being conducted at the school that require high-resolution mass spectrometry, according to the abstract. A high-resolution A-TOF system would be used in upper-level chemistry and biochemistry courses.


Title: Acquisition of a MALDI-TOF Mass Spectrometer
Principal Investigators: Paramjit Arora; Michael Ward; James Canary Sponsor: New York University
Start/End Date: Jan. 1, 2010 – Dec. 31, 2012
Amount Awarded to Date: $295,919

Among the projects that the instrument would be used for are ones looking into protein mimetics; bioaffinity interactions and microarray technologies, and "charge transfer interactions in crystals and their relevance to MALDI mass spectrometry," according to the abstract.


Title: Acquisition of a Benchtop Electrospray Ionization Time-of-Flight Mass Spectrometer
Principal Investigators: Vaidhyanathan Ramamurthy; Angel Kaifer; Francisco Raymo; Norito Takenaka; Burjor Captain
Sponsor: University of Miami
Start/End Date: Jan. 1, 2010 – Dec. 31, 2012
Amount Awarded to Date: $308,800

Funds the purchase of an LC-MS system, which will be used to study protein signaling pathways, as well as to study molecular self-assembly, and other things.


Title: Acquisition of a Quadrupole Time-of-Flight Mass Spectrometer
Principal Investigators: Christa Colyer; Rebecca Alexander Sponsor: Wake Forest University
Start/End Date: Jan. 1, 2010 – Dec. 31, 2012
Amount Awarded to Date: $442,102

The instrument will be used to support research into "modeling biological networks in Arabidopsis through integration of genomic, proteomic, and metabolomic data," according to the abstract, as well as "affinity-based capillary electrophoresis … to facilitate bioprobe designs and microbe detection."

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.