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Funding Update: Sep 24, 2009

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Title: New ABPP probes and sample preparation methods for biomarker discoveries
Principal Investigators: Feng Tao
Sponsor: Omic Biosystems
Start/End Date: Jan. 1, 2010 – June 30, 2010
Award Amounted to Date: $149,996

The project aims to identify and quantify functional proteins in small size, dilute, and/or archived samples using mass spectrometric analysis. Novel chemical biology and sample preparation strategies are proposed. The set of specific reagents to be developed is composed of specific activity-based protein profiling probes, cleavable high-affinity solid support conjugation for quantitative target enrichment, and stable isotopic labels for mass spec identification and quantification. An enabling sample-prep method to be used prior to MS analysis will also be optimized for ABPP probe labeling. Commercial kits will be made at the end of the project for life-science laboratories conducting proteomic research.


Title: Acquisition of instrumentation for Proteomics Research or Training Encompassing Investigators' Needs lab at SJSU (PROTEIN Lab)
Principal Investigators: Brandon White; Marc d'Alarcao
Sponsor: San Jose State University Foundation
Start/End Date: Sept. 15, 2009 – Aug. 31, 2012
Award Amounted to Date: $802,349

Funds the creation of a proteomics facility to develop faculty expertise in molecular life science research and train students in proteomics. "This program will enable a variety of scientific advances, including identification of novel proteins in biological signal transduction pathways, characterization of novel proteins from diverse biological sources such as uncultivable bacteria to humans, purification of proteins for biophysical studies of protein crowding and hydration effects, and characterization of small molecules," according to the abstract.


Title: Acquisition of a triple quadrupole mass spectrometer for interdisciplinary undergraduate research and teaching in chemistry and biology
Principal Investigators: Christine Hughey; Jennifer Funk; Jason Keller
Sponsor: Chapman University
Start/End Date: Sept. 15, 2009 – Aug. 31, 2012
Award Amounted to Date: $414,521

Funds the acquisition of a triple quadrupole mass spectrometer which will fund three research projects: targeted quantitation of plan proteomics; small-molecule quantitation "for fundamental negative ion electrospray ionization studies," according to the abstract; and small-molecule quantitation of alcohol and acid intermediates formed during anaerobic decomposition of wetland organic matter.


Title: Single-biomolecule detector array based on nanomagnetically stabilized magnetoresistive sensors
Principal Investigators: Dmitri Litvinov; Richard Willson; Chung-Che Chang
Sponsor: University of Houston
Start/End Date: Sept. 15, 2009 – Aug. 31, 2011
Award Amounted to Date: $202,439

Supports research aimed at demonstrating the utility of a novel biosensor platform "capable of unprecedentedly high sensitivity, potentially at a single-molecule level, to biomolecular agents such as DNA, RNA, proteins, antibodies, or pathogens, opening new opportunities in diagnosis and in biological research," according to the abstract. The technology leverages advancements in nanomagnetic sensor technology.


Title: Acquisition of integrated infrastructure enabling multidisciplinary research in systems biology
Principal Investigators: Shane Burgess; Susan Bridges; Ioana Banicescu; Daniel Peterson; Bindumadhavi Nanduri
Sponsor: Mississippi State University
Start/End Date: Sept. 15, 2009 – Aug. 31, 2012
Award Amounted to Date: $800,867

Funds the purchase of a Thermo Fisher Scientific LTQ Velos Orbitrap mass spectrometer for quantifying and describing proteins and their modifications. Specific projects that will use the instrument include enabling proteomics mass spectrometrists "to derive more value from their mass spectral data by combining quantum mechanics computation with experimental and computational proteomics using new algorithms for peptide/protein identification" according to the abstract; using computational systems biology and experimental validation to explain how complex interconnected functional networks of proteins, metabolites, nucleic acids, and other molecules "orchestrate cellular functions and responses to external and intrinsic signals; and genome-wide mapping of the histone state and epigenetic regulatory networks in Arabidopsis.


Title: Acquisition of a 9.4 T high field Fourier transform ion cyclotron resonance mass spectrometer for biological and materials applications
Principal Investigators: Mary Rodgers; Peter Armentrout; Andrew Feig; Christine Chow; Mary Kay Pflum
Sponsor: Wayne State University
Start/End Date: Sept. 15, 2009 – Aug. 31, 2012
Award Amounted to Date: $757,870

The purchase of the FT-ICR mass spectrometry will be used to establish a biological mass spectrometry resource. In addition to proteomics, the platform will be used for glycomics, lipidomics, metabolomics, genomics, and drug development research.


Title: Acquisition of an LC-MS/MS mass spectrometer by Cleveland State University
Principal Investigators: Yan Xu; David Anderson
Sponsor: Cleveland State University
Start/End Date: Sept. 15, 2009 – Aug. 31, 2012
Award Amounted to Date: $514,962

The platform being purchased will be used for a "wide range" of scientific an engineering fields, including analytical chemistry, organic chemistry; clinical chemistry, and others, according to the abstract.


Title: Acquisition of an LCMS-TOF mass spectrometer for interdisciplinary research
Principal Investigators: Brent Feske; Richard Wallace; Delana Nivens;
Scott Mateer; Karla-Sue Marriott
Sponsor: Armstrong Atlantic State University
Start/End Date: Sept. 15, 2009 – Aug. 31, 2012
Award Amounted to Date: $277,326

Research that will conducted with the instrument include projects directed at the interactions of copper-containing proteins and complexes with biological molecules.

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