Expanded Proximity Ligation Assay Could Prove Valuable for Biomarker Studies, Top-Down Proteomics | GenomeWeb

By Adam Bonislawski

Uppsala University scientists have developed an expanded proximity ligation assay that employs up to five antibodies to confirm the simultaneous presence of multiple proteins on a given target.

The researchers used the technique to isolate prostasomes — microvesicles secreted by prostate acinar cells that could be useful as prostate cancer biomarkers — but it could have wider applicability as a tool for top-down proteomics investigations into protein complexes and isoforms.

Get the full story with
GenomeWeb Premium

Only $95 for the
first 90 days*

A trial upgrade to GenomeWeb Premium gives you full site access, interest-based email alerts, access to archives, and more. Never miss another important industry story.

Try GenomeWeb Premium now.

Already a GenomeWeb Premium member? Login Now.
Or, See if your institution qualifies for premium access.

*Before your trial expires, we’ll put together a custom quote with your long-term premium options.

Not ready for premium?

Register for Free Content
You can still register for access to our free content.

The Wall Street Journal reports that National Institutes of Health Director Francis Collins' response to contamination concerns at the agency might have delayed care.

The final revision of the Common Rule doesn't include the proposed change requiring consent for leftover biospecimens.

The first Reproducibility Project: Cancer Biology papers show mixed results.

In Nature this week: mobile phone-based targeted DNA sequencing, and more.