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European Bioinformatics Institute, Bio-Rad, Peter Schulz-Knappe, Robert Petcavich, Robert Bondaryk, Nick Roelofs, David Simmons


New Products

The European Bioinformatics Institute has released an updated version of the International Protein Index database at The database, compiled from UniProt, RefSeq, Ensembl, TAIR, and H-InvDB, includes protein data for human, mouse, rat, zebrafish, Arabidopsis, chicken, and cow.

Bio-Rad has released the MicroRotofor cell, an instrument for enriching low-abundance proteins for biomarker discovery. According to the company, the MicroRotofor cell enables formerly undetectable proteins to be enriched to levels that allow analysis by 2D gel electrophoresis/mass spectrometry and liquid chromatography/tandem mass spectrometry.

The MicroRotofor cell, a preparative isoelectric focusing device that fractionates complex protein samples in free solution, can be used alone or as a part of a broader separation or purification workflow, Bio-Rad said. The system fractionates by liquid-phase isoelectric focusing, "which is particularly beneficial for proteins that are insoluble or otherwise do not separate well in other, gel-based IEF media," the company said in a statement.

Clarification: In an interview in the 06-22-06 issue of ProteoMonitor, Michael Schubert's comments regarding Bruker Daltonics' manufacturing relationship with Agilent Technologies omitted some details of the companies' partnership. Agilent develops the ion sources, ion transfer optics, vacuum systems, chassis, and associated control electronics used in the ion trap systems discussed in the interview. Bruker performs the final assembly and testing for the traps, which are built with components developed by Agilent, Bruker, and other third-party providers.


Movers & Shakers

Proteome Sciences has hired Peter Schulz-Knappe as R&D director and CSO. Schulz-Knappe will join the firm on Aug. 1 and will split his responsibilities between the company's headquarters in Cobham, UK, and its laboratories in Frankfurt and London.

Schulz-Knappe was CSO and founder of biomarker-discovery firm BioVision prior to its acquisition by Digilab in February. Prior to that, he led the Lower Saxony Institute of Peptide Chemistry.

Robert Petcavich has left his post as senior vice president and CTO at Lumera to pursue other business interests, according to a company statement. Lumera said that it reorganized into two operational business units earlier this year, which placed technology development under the direction of the business unit heads.

Clinical Data has appointed Robert Bondaryk as general manager and unit head of its Cogenics division.

Formerly an executive vice president and general manager of business development at Proteome Systems, Bondaryk also spent time as vice president of life science and drug discovery at Fisher Scientific. He was vice-president of corporate development at Pharm-Eco Laboratories, co-founder and president of Medtech Capital, and senior consultant at Arthur D. Little.

Agilent Technologies has named Nick Roelofs as vice president and general manager of its life sciences solutions division.

Previously, Roelofs was group operations officer for the life science group at Bio-Rad Laboratories. He also served as chief operating officer of Stratagene. He has held senior positions at Applied Biosystems and Baxter Diagnostic.

David Simmons has joined Cellzome as chief scientific officer.

For the past three years, Simmons was vice-president of inflammation discovery research at Wyeth Research and co-chair of the Inflammation Therapeutic Area Leadership team.

Before Wyeth, he was director of research at Celltech and group director of neuroscience research at SmithKline Beecham Pharmaceuticals.

The Scan

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In dozens of domestic dogs listening to wolf vocalizations, researchers in Communication Biology see responses varying with age, sex, reproductive status, and a breed's evolutionary distance from wolves.

Facial Imaging-Based Genetic Diagnoses Appears to Get Boost With Three-Dimensional Approach

With data for more than 1,900 individuals affected by a range of genetic conditions, researchers compared facial phenotype-based diagnoses informed by 2D or 3D images in the European Journal of Human Genetics.

Survey Suggests Multigene Cancer Panel VUS Reporting May Vary Across Genetic Counselors

Investigators surveyed dozens of genetic counselors working in clinical or laboratory settings, uncovering attitudes around VUS reporting after multigene cancer panel testing in the Journal of Genetic Counseling.

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.