Like a locomotive pulling into the station to pick up its passengers, in late July the Department of Energy's Genomes to Life project rolled into the proteomics world with $103 million worth of steam. Those to land a first class seat include three groups of researchers from both government and academic labs who plan to use large scale proteome analysis techniques. The focus of their pursuits: the machinations of microorganisms associated with the DOE’s goals of clean energy production and environmental remediation.