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Dataset Available for iPRG's 2011 Mass Spectra Identification Study

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This story originally ran on Oct. 27.

The Proteome Informatics Research Study Group of the Association of Biomolecular Resource Facilities has announced the availability of the dataset for its 2011 mass spectra identification study.

This year's study will focus on the identification of electron transfer disassociation spectra. Because ETD spectra differ considerably from traditional collision-induced dissociation spectra, the automated interpretation of ETD spectra requires new approaches. The study aims to enable researchers to evaluate and compare their ETD data analysis techniques.

The dataset to be provided for analysis will come from a yeast lysate digested with Lys-C and enriched for highly charged peptides using cation exchange fractionation. Participating labs will receive access to the mass spectral data in several formats, a reference FASTA formatted protein sequence database, a suitable peptide mass spectral library, and a template for reporting study results.

Along with lists of identified spectra, researchers will be required to submit a web-based questionnaire summarizing their methods. The results will be presented at the ABRF 2011 meeting Feb. 19-22 in San Antonio, and data from additional LC-MS/MS runs of the study samples and neighboring SCX fractions collected using CID and HCD will be released to participants to be used in further algorithm development.

Requests to participate should be submitted by email to [email protected] by Oct 29.