The Case Western Reserve University School of Medicine said this week it has received a five-year, $4 million grant from the National Institute of Biomedical Imaging and Bioengineering to the Case Center for Synchrotron Biosciences to support research into the structure and dynamics of proteins and nucleic acids. .
NIBIB is part of the National Institutes of Health.
The center, located at Brookhaven National Laboratory in upstate New York, has three technology cores that will be funded by the grant: the footprinting core, based on its X28C footprinting beamline; the X-ray spectroscopy core, based on the X3B beamline; and the macromolecular crystallography core.
The footprinting core will provide facilities for the study of proteins and nucleic acids, including in vivo studies. Novel structural mass spectrometry and proteomics approaches invented in the center will be used by scientists for investigations into large macromolecular structures and membrane proteins, the university said in a statement.
The X-ray spectroscopy core will receive a detector upgrade "bringing its capabilities to state-of-the-art" in the US, the university said. Here, researchers will study the role of metal atoms in proteins.
And the macromolecular crystallography core "will provide one of the most productive macromolecular crystallography facilities in the world," Case Western Reserve said.
The center will support more than 175 projects across the three cores supported by 212 peer-reviewed grants.
"These studies are critical for understanding the normal biology of all organisms and the molecular effects of disease including the design of drugs to control cellular processes and the understanding of the molecular interactions that mediate the spread of viruses and bacteria," Mark Chance, director of the center, said.