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CPTAC Releases Proteomic, Phosphoproteomic, Glycoproteomic Ovarian Cancer Datasets


NEW YORK (GenomeWeb News) – The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium this week released a comprehensive dataset of proteomic analyses of 174 high grade serous ovarian tumor samples previously analyzed by The Cancer Genome Atlas initiative.

The work was performed by researchers at Johns Hopkins University, which focused on glycoproteomic analysis, and Pacific Northwestern National Lab, which focused on the proteomic and phosphoproteomic analyses.

The datasets as well as corresponding metadata are publicly available at the CPTAC Data Portal.

The ovarian dataset is the third large dataset released by CPTAC researchers, following colorectal and breast cancer datasets that were released in 2013 and 2014, respectively.

Launched in August of 2011, CPTAC 2 – a five-year project slated to cost between $75 million and $120 million – aims to combine protein biomarker discovery and verification studies in tumor tissue samples with genomic characterizations of those same samples done by TCGA.

The effort builds on the initial five-year, $104 million CPTC initiative launched in 2006, which worked to build a foundation of technologies and standards to advance the application of proteomics to cancer research. That project established five multidisciplinary, multi-institution research centers and developed collaborations with more than 60 public and private institutions around the world.